| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CD103; HUMINAE |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ITGAE |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ITGAE(CD103)抗体的虚构参考文献示例(仅供格式参考)：
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1. **文献名称**: *CD103+ T cells in tumor immunity: Role of ITGAE antibodies in tracking cytotoxic lymphocyte subsets*
**作者**: Smith, J.R. et al.
**摘要**: 本研究利用ITGAE特异性抗体，通过流式细胞术分析肿瘤微环境中CD103+ T细胞的浸润情况，揭示其与患者预后的正相关性，为免疫治疗提供新靶点。
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2. **文献名称**: *Regulation of intestinal CD103 expression by ITGAE-targeting antibodies in inflammatory bowel disease*
**作者**: Li, X. & Wang, H.
**摘要**: 通过ITGAE抗体阻断实验，证实CD103在肠道上皮内淋巴细胞中的黏附功能，并发现其表达失调与炎症性肠病(IBD)的病理进展密切相关。
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3. **文献名称**: *ITGAE antibody-based imaging reveals dendritic cell migration dynamics in lymphoid tissues*
**作者**: García, M. et al.
**摘要**: 采用ITGAE抗体进行活体成像，首次可视化树突状细胞依赖CD103整合素的迁移路径，阐明了其在次级淋巴器官中的免疫监视机制。
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**注**：以上文献为示例，实际引用请通过PubMed或Google Scholar检索真实文献(关键词：ITGAE antibody, CD103. integrin alphaE)。
ITGAE antibody targets the integrin alpha E subunit (CD103), a cell surface protein encoded by the ITGAE gene. Integrins are heterodimeric transmembrane receptors involved in cell adhesion, migration, and signaling. The αE subunit pairs exclusively with the β7 subunit (integrin αEβ7), forming a receptor that binds E-cadherin on epithelial cells. This interaction mediates lymphocyte retention in epithelial tissues, particularly in mucosal and barrier surfaces.
CD103 is predominantly expressed on intraepithelial lymphocytes (IELs), regulatory T cells (Tregs), and dendritic cells in mucosal areas. Its role in immune surveillance and tolerance makes it a key marker for studying tissue-resident immune populations. ITGAE antibodies are widely used in immunology research to identify and isolate CD103+ cells, analyze their function in inflammatory responses, and explore their involvement in diseases such as inflammatory bowel disease (IBD), cancer, and autoimmune disorders.
In cancer research, CD103+ T cells are associated with improved prognosis in epithelial tumors, as they may enhance antitumor immunity. Conversely, in chronic inflammation, CD103+ immune cells can contribute to tissue damage. ITGAE antibodies are also utilized in flow cytometry, immunohistochemistry, and functional assays to investigate adhesion mechanisms and therapeutic targeting. Their applications extend to developing immunotherapies aimed at modulating integrin-mediated interactions in disease contexts.
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