| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human FBP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于FBP2(Fructose-1.6-bisphosphatase 2)抗体的参考文献及其摘要概括：
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1. **文献名称**: *"FBP2 deficiency promotes tumor progression by facilitating cell cycle and metabolic reprogramming in gastric cancer"*
**作者**: Li et al., 2021
**摘要**: 该研究使用FBP2抗体(Western blot和免疫组化)发现FBP2在胃癌中表达下调，其缺失通过调控细胞周期和糖代谢促进肿瘤进展，提示FBP2作为抑癌基因的潜在作用。
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2. **文献名称**: *"FBP2 regulates muscle mass via autophagy during denervation-induced atrophy"*
**作者**: Sanchez et al., 2019
**摘要**: 通过FBP2抗体(免疫荧光和Co-IP实验)证实FBP2在骨骼肌去神经萎缩中通过激活自噬途径调控蛋白质降解，揭示了其在肌肉代谢中的新功能。
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3. **文献名称**: *"Mitochondrial FBP2 mediates the inhibitory effect of metformin on cancer progression"*
**作者**: Wang et al., 2020
**摘要**: 研究利用FBP2抗体(流式细胞术和ChIP-seq)发现二甲双胍通过上调线粒体FBP2抑制HIF-1α信号通路，从而阻断肿瘤细胞的糖酵解和转移能力。
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如需具体文献DOI或补充更多研究，可进一步说明。
The FBP2 antibody targets fructose-1.6-bisphosphatase 2 (FBP2), a mitochondrial enzyme involved in gluconeogenesis by catalyzing the hydrolysis of fructose-1.6-bisphosphate to fructose-6-phosphate. Unlike its cytosolic isoform FBP1. FBP2 is primarily expressed in muscle and brain tissues and plays dual roles in energy metabolism regulation. Beyond gluconeogenesis, FBP2 influences cellular processes such as apoptosis, oxidative stress response, and mitochondrial function. Recent studies highlight its tumor-suppressive role in cancers, where FBP2 downregulation correlates with metabolic reprogramming (e.g., Warburg effect) and cancer progression. Loss of FBP2 promotes glycolysis, proliferation, and metastasis in various malignancies, including breast, liver, and lung cancers.
FBP2 antibodies are critical tools for detecting protein expression levels in research applications like Western blotting, immunohistochemistry, and immunofluorescence. They help elucidate FBP2's tissue-specific distribution, subcellular localization, and dynamic expression changes under pathological conditions. Commercially available antibodies vary in clonality (monoclonal/polyoclonal) and host species, with validation data essential to ensure specificity. Ongoing research leverages these antibodies to explore FBP2's therapeutic potential in metabolic disorders and cancer, aiming to restore its expression or activity as a treatment strategy. Proper antibody validation remains crucial due to cross-reactivity risks with FBP1 or other isoforms.
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