| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ETS2IT1 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ETS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ETS2抗体的3篇参考文献示例(注：内容为模拟概括，仅供参考)：
1. **"Development and validation of a monoclonal antibody specific for human ETS2 transcription factor"**
- 作者：Smith A, et al.
- 摘要：该研究描述了一种新型抗人ETS2单克隆抗体的开发与验证。通过Western blot和免疫组化实验证实了抗体在多种细胞系及组织中的特异性，并应用于研究ETS2在肿瘤发生中的表达调控。
2. **"ETS2 phosphorylation status detected by phospho-specific antibodies correlates with metastatic potential in colorectal cancer"**
- 作者：Chen L, et al.
- 摘要：研究团队开发了针对ETS2磷酸化位点的特异性抗体，发现其在结直肠癌转移样本中高表达，揭示了ETS2磷酸化状态与癌症侵袭性的关联，为预后评估提供潜在标志物。
3. **"Role of ETS2 in endothelial cell angiogenesis: Insights from antibody-based functional studies"**
- 作者：Wang Y, et al.
- 摘要：通过使用商业化ETS2抗体进行染色质免疫沉淀(ChIP)和敲低实验，本文阐明了ETS2在血管内皮细胞血管生成中的调控机制，强调其与VEGF信号通路的相互作用。
建议通过PubMed或Google Scholar检索最新文献，以获取真实准确的引用信息。
The ETS2 antibody targets the ETS2 protein, a member of the ETS (E26 transformation-specific) family of transcription factors. ETS2 is encoded by the *ETS2* gene and plays a critical role in regulating gene expression involved in cell proliferation, differentiation, apoptosis, and oncogenesis. It binds to DNA via a conserved ETS domain, recognizing GGAA/T-rich sequences in promoter or enhancer regions of target genes. ETS2 is implicated in various biological processes, including embryonic development, immune response, and tissue remodeling, and its dysregulation has been linked to cancers (e.g., prostate, breast, colorectal) and inflammatory diseases.
Antibodies against ETS2 are widely used in research to study its expression, localization, and function. They enable techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP), helping to elucidate ETS2’s role in signaling pathways (e.g., MAPK/ERK) and its interaction with co-regulators. Commercial ETS2 antibodies are typically validated for specificity using knockout controls or siRNA knockdown. Researchers must consider factors like antibody clonality (monoclonal vs. polyclonal), host species, and epitope regions when selecting reagents. Despite its importance, cross-reactivity with homologous ETS family members (e.g., ETS1) remains a potential challenge, necessitating careful experimental design. Overall, ETS2 antibodies are vital tools for exploring its contributions to normal physiology and disease pathology.
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