| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MKP8; LDP-4; NATA1; SKRP3; DUSP24 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DUSP26 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于DUSP26抗体的参考文献示例(注：文献信息为虚构，仅供格式参考)：
1. **文献名称**: "DUSP26 regulates apoptosis and cell migration in neuroblastoma through AKT signaling"
**作者**: Smith A, et al.
**摘要**: 使用特异性DUSP26抗体检测其在神经母细胞瘤中的表达，发现DUSP26通过抑制AKT磷酸化促进肿瘤细胞凋亡并抑制迁移。
2. **文献名称**: "Development of a monoclonal antibody against human DUSP26 for immunohistochemical applications"
**作者**: Zhang L, et al.
**摘要**: 报道一种新型兔源单克隆DUSP26抗体的开发与验证，该抗体可用于Western blot和免疫组化，成功应用于肺癌组织样本中DUSP26蛋白定位研究。
3. **文献名称**: "DUSP26 modulates oxidative stress responses via JNK/p38 pathways in neuronal cells"
**作者**: Brown K, et al.
**摘要**: 通过DUSP26抗体结合免疫荧光技术，揭示DUSP26在小鼠神经元细胞中负调控JNK/p38信号通路，影响氧化应激耐受性。
4. **文献名称**: "DUSP26 as a tumor suppressor in thyroid cancer: Antibody-based expression profiling"
**作者**: Chen X, et al.
**摘要**: 利用DUSP26抗体对甲状腺癌临床样本进行表达分析，发现DUSP26低表达与肿瘤转移和不良预后显著相关，提示其抑癌功能。
(注：以上内容为模拟生成，实际文献需通过PubMed、Google Scholar等平台检索确认。)
The DUSP26 antibody is a critical tool for studying the dual-specificity phosphatase 26 (DUSP26), a member of the protein tyrosine phosphatase (PTP) family. DUSP26. also known as MKP-8 or LDP-3. is a phosphatase that deactivates mitogen-activated protein kinases (MAPKs) by removing phosphate groups from both tyrosine and serine/threonine residues. It plays roles in regulating cellular processes like proliferation, differentiation, and apoptosis. DUSP26 is of particular interest in cancer research due to its dual roles, acting as either an oncogene or tumor suppressor depending on the cellular context. For instance, it is overexpressed in neuroblastoma and thyroid cancer but downregulated in hepatocellular carcinoma.
The DUSP26 antibody enables the detection and quantification of DUSP26 protein levels in various experimental settings, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Researchers use it to investigate DUSP26's expression patterns, subcellular localization (primarily cytoplasmic), and interactions with signaling pathways. Its specificity is validated through knockout controls or siRNA-mediated silencing to ensure accurate results. Challenges in studying DUSP26 include its low expression in certain tissues and contradictory findings across cancer types. Reliable antibodies are essential for clarifying its regulatory mechanisms and therapeutic potential, emphasizing the need for rigorous validation to ensure reproducibility in studies targeting DUSP26-related diseases.
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