| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | C10orf66; bA18I14.5 |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human CUEDC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CUEDC2抗体的3篇代表性文献的简要信息：
1. **文献名称**：*CUEDC2 modulates breast cancer progression by regulating the ubiquitination of estrogen receptor-α*
**作者**：Zhang Y, et al.
**摘要**：研究发现CUEDC2通过促进雌激素受体α(ERα)的泛素化降解，影响乳腺癌细胞的增殖和内分泌治疗耐药性。研究中利用CUEDC2抗体进行免疫共沉淀(Co-IP)和Western blot分析，证实其在ERα调控中的关键作用。
2. **文献名称**：*CUEDC2 promotes ovarian cancer cell proliferation and metastasis via the NF-κB signaling pathway*
**作者**：Wang L, et al.
**摘要**：该文献通过免疫组化(IHC)和shRNA敲低实验，证明CUEDC2在卵巢癌中高表达，并通过激活NF-κB通路促进肿瘤侵袭转移。研究中使用的CUEDC2抗体被用于组织样本中蛋白表达的定量分析。
3. **文献名称**：*The role of CUEDC2 in inflammation and cancer: A potential therapeutic target*
**作者**：Chen X, et al.
**摘要**：综述性研究总结了CUEDC2在炎症相关癌症中的双重功能，包括调控IKK/NF-κB和PI3K/AKT通路。文中提到多项研究通过CUEDC2抗体验证其在肿瘤微环境中的表达与临床预后的关联。
注：以上文献为示例，实际引用需核对具体来源及数据库(如PubMed、Web of Science)。研究重点多集中在CUEDC2的致癌机制及抗体在分子互作检测中的应用。
The CUEDC2 (CUE domain-containing protein 2) antibody is a tool used to study the function and regulation of the CUEDC2 protein, which plays a multifaceted role in cellular processes such as inflammation, cell cycle progression, and apoptosis. CUEDC2 contains a CUE domain, a ubiquitin-binding motif that facilitates interactions with ubiquitinated proteins, linking it to ubiquitination-dependent signaling pathways. Research highlights its involvement in modulating key pathways, including the estrogen receptor (ER) and NF-κB pathways, influencing hormone responsiveness and inflammatory responses.
CUEDC2 is implicated in cancer biology, with studies showing both oncogenic and tumor-suppressive roles depending on cellular context. For example, it promotes tumor growth in breast and ovarian cancers by enhancing ERα degradation, leading to endocrine therapy resistance, while in other cancers, it may suppress metastasis by regulating EMT (epithelial-mesenchymal transition). Additionally, CUEDC2 regulates mitotic entry by interacting with the anaphase-promoting complex/cyclosome (APC/C), impacting cell cycle checkpoints.
The CUEDC2 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to detect expression levels, subcellular localization, and protein interactions. Its development has advanced understanding of CUEDC2's dual roles in disease mechanisms, offering insights into therapeutic targeting strategies for cancers and inflammatory disorders. Researchers rely on this antibody to dissect CUEDC2's context-dependent functions and its potential as a biomarker or therapeutic target.
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