| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ODG2; POF4; GDF9B |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human BMP15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BMP15抗体的3篇参考文献及其简要摘要：
1. **文献名称**: *"Production and characterization of a polyclonal antibody against human BMP-15"*
**作者**: Aaltonen J, et al.
**摘要**: 该研究报道了一种针对人BMP15蛋白多克隆抗体的制备方法，并通过Western blot和免疫组织化学验证了其在人卵巢组织中的特异性，证实抗体可用于检测BMP15在卵泡颗粒细胞中的表达。
2. **文献名称**: *"BMP15 mutations and ovarian function: Role of antibody-based detection in premature ovarian insufficiency"*
**作者**: Persani L, et al.
**摘要**: 研究利用BMP15特异性抗体分析卵巢早衰患者的突变BMP15蛋白表达，发现抗体能有效识别突变体，揭示了BMP15异常与卵巢功能衰退的关联。
3. **文献名称**: *"Development of a monoclonal antibody for BMP15 and its application in mammalian reproductive studies"*
**作者**: Yan C, et al.
**摘要**: 开发了一种高亲和力单克隆抗体，通过免疫沉淀和免疫荧光技术证实其在小鼠和人类卵巢组织中的适用性，为研究BMP15在哺乳动物卵泡发育中的作用提供了工具。
4. **文献名称**: *"Immunolocalization of BMP15 in bovine oocytes and its role in in vitro maturation"*
**作者**: Sugiura K, et al.
**摘要**: 利用抗BMP15抗体定位牛卵母细胞中的BMP15蛋白，发现其通过旁分泌信号调控卵丘扩展，抗体阻断实验进一步证明BMP15对卵母细胞成熟的必要性。
这些文献涵盖了抗体开发、疾病机制研究和生殖生物学应用，均涉及BMP15抗体的实验验证与功能分析。
BMP15 (Bone Morphogenetic Protein 15), a member of the transforming growth factor-β (TGF-β) superfamily, is a critical oocyte-secreted factor regulating folliculogenesis and female fertility. Primarily expressed in oocytes, BMP15 interacts with granulosa cells to modulate follicular development, ovulation, and luteinization. It functions synergistically with GDF9 (Growth Differentiation Factor 9) to promote early follicle growth, inhibit premature luteinization, and maintain oocyte quality. Dysregulation of BMP15 is linked to reproductive disorders such as premature ovarian insufficiency (POI) and polycystic ovary syndrome (PCOS).
BMP15 antibodies are essential tools for studying its expression, localization, and function in reproductive tissues. These antibodies enable detection of BMP15 in immunoassays (e.g., Western blot, immunohistochemistry) and facilitate research into its signaling pathways, including interactions with receptors (e.g., BMPR2. ACVR1B) and downstream SMAD proteins. Clinically, BMP15 antibodies may aid in diagnosing fertility-related conditions or developing therapeutic strategies, such as ovarian stimulation protocols. Challenges include ensuring antibody specificity due to structural similarities among TGF-β family members. Recent studies also explore BMP15's role in non-reproductive systems, expanding its potential biomedical relevance.
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