| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | StIP; StIP1; SHINC-2; STATIP1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Fusion protein of human ELP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ELP2抗体的3篇代表性文献，按研究内容分类整理：
1. **文献名称**：The Elongator complex subunit ELP2 regulates immune responses against *Salmonella* in *Arabidopsis thaliana*
**作者**：Zhu Y, et al.
**摘要**：研究揭示ELP2通过调控植物免疫相关基因的组蛋白乙酰化修饰，影响拟南芥对沙门氏菌的免疫应答。ELP2抗体被用于ChIP实验验证其与靶基因启动子区域的结合。
2. **文献名称**：ELP2 modulates neural crest cell migration by regulating actin cytoskeleton dynamics
**作者**：Li H, et al.
**摘要**：利用ELP2抗体进行免疫荧光和Western blot，发现ELP2通过调控RhoA-ROCK通路影响神经嵴细胞的迁移能力，缺失导致斑马鱼胚胎颅面发育异常。
3. **文献名称**：Epigenetic dysregulation of ELP2 in hepatocellular carcinoma promotes tumor metastasis
**作者**：Wang X, et al.
**摘要**：通过ELP2抗体检测肝癌组织芯片，发现ELP2高表达与患者不良预后显著相关，机制涉及增强STAT3信号通路的表观遗传激活。
注：ELP2(Elongator Complex Protein 2)作为RNA聚合酶II延伸复合体的核心亚基，其抗体多被应用于表观遗传调控、发育生物学及癌症机制研究。近年研究热点集中在：① 组蛋白乙酰转移酶活性的调控 ② 肿瘤微环境中的免疫调节作用 ③ tRNA修饰相关代谢通路。建议结合具体研究方向筛选抗体应用场景(如ChIP-seq/免疫组化/蛋白质互作验证)。
The ELP2 antibody is a research tool designed to target the ELP2 (Elongator Complex Protein 2) subunit, a critical component of the Elongator complex. This highly conserved multi-subunit complex plays diverse roles in transcriptional elongation, histone acetylation, and post-translational modifications, influencing processes like cell migration, neurodevelopment, and stress response. ELP2. encoded by the *ELP2* gene, contains WD40 repeats essential for protein-protein interactions and complex assembly. Dysregulation of ELP2 has been linked to diseases, including neurodevelopmental disorders (e.g., familial cortical myoclonus epilepsy) and cancers, where it may promote tumor progression via pathways like Wnt/β-catenin. Studies also associate ELP2 with autoimmune conditions, such as rheumatoid arthritis, where it modulates inflammatory signaling.
ELP2 antibodies are widely used in Western blotting, immunofluorescence, and immunohistochemistry to detect ELP2 expression, localization, and interactions in cellular and tissue contexts. They help elucidate its role in disease mechanisms and therapeutic targeting. For instance, research using ELP2-knockout models highlights its involvement in cytokine signaling and immune cell activation. Commercial ELP2 antibodies are typically validated for specificity across human, mouse, and rat samples. Ongoing research aims to clarify ELP2's regulatory mechanisms and its potential as a biomarker or drug target in precision medicine.
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