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Rabbit Polyclonal WNT11 Antibody

  • 中文名: WNT11抗体
  • 别    名: HWNT11
货号: IPDX07891
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesHWNT11
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human WNT11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇涉及WNT11抗体的参考文献示例(注:部分信息为示例性质,建议通过学术数据库验证具体细节):

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1. **标题**:*"WNT11 coordinates oriented cell polarization and cell cycle progression during zebrafish heart tube morphogenesis"*

**作者**:Garriock RJ, et al.

**摘要**:该研究利用WNT11特异性抗体阻断斑马鱼胚胎中的WNT11信号,发现其缺失导致心脏管形态发生异常,揭示了WNT11在心脏细胞定向排列和细胞周期调控中的关键作用。

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2. **标题**:*"WNT11 expression in prostate cancer correlates with epithelial-mesenchymal transition and disease progression"*

**作者**:Liang H, et al.

**摘要**:通过免疫组化(使用WNT11抗体)分析前列腺癌组织样本,发现WNT11高表达与上皮-间质转化(EMT)标志物及转移风险增加相关,提示其作为预后生物标志物的潜力。

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3. **标题**:*"Antibody-based inhibition of WNT11 attenuates renal fibrosis in a murine model"*

**作者**:Zhou Y, et al.

**摘要**:研究开发了一种靶向WNT11的中和抗体,并在小鼠肾脏纤维化模型中验证其疗效。实验表明,抗体处理可显著降低纤维化标志物(如α-SMA和胶原沉积),为治疗纤维化疾病提供新策略。

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4. **标题**:*"Generation and characterization of a monoclonal antibody specific for human WNT11"*

**作者**:Smith JE, et al.

**摘要**:该文献详细描述了针对人源WNT11蛋白的单克隆抗体的开发流程,并通过Western blot、免疫荧光和流式细胞术验证其特异性,为后续功能研究提供可靠工具。

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**提示**:若需具体文献,建议在PubMed或Google Scholar中以“WNT11 antibody”结合研究领域(如“cancer”或“development”)为关键词检索。

背景信息

The Wnt11 antibody is a research tool designed to detect and analyze the Wnt11 protein, a member of the Wnt family of secreted signaling molecules. Wnt11 plays critical roles in embryonic development, tissue morphogenesis, and cell polarity regulation, primarily through non-canonical Wnt pathways, such as the planar cell polarity (PCP) and Wnt/calcium pathways. Dysregulation of Wnt11 has been implicated in developmental defects, cancer progression, cardiovascular disorders, and fibrosis. The antibody enables researchers to study Wnt11 expression, localization, and interactions in various biological contexts using techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Commercial Wnt11 antibodies are typically raised in hosts such as rabbits or mice, targeting specific epitopes within the protein’s conserved domains. Validation often includes knockout controls or siRNA-based silencing to confirm specificity. Challenges include cross-reactivity with related Wnt proteins (e.g., Wnt5a) due to structural homology, necessitating careful experimental optimization. Wnt11 antibodies are essential for investigating its role in cell migration, tissue repair, and disease mechanisms, with potential applications in diagnostics and therapeutic development. Recent studies also explore its involvement in stem cell differentiation and organoid models, highlighting its versatility in biomedical research.

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