| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SOCS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与SOCS2抗体相关的代表性文献及其摘要概括：
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1. **文献名称**：*"SOCS2 regulates growth hormone receptor signaling via ubiquitin-proteasome pathway"*
**作者**：Greenhalgh CJ 等
**摘要**：该研究利用SOCS2特异性抗体，发现SOCS2通过泛素-蛋白酶体途径负调控生长激素受体(GHR)信号，过表达SOCS2会抑制生长激素介导的STAT5激活，揭示了其在代谢调控中的作用机制。
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2. **文献名称**：*"SOCS2 deficiency leads to partial resistance to LPS-induced septic shock and sustained STAT3 activation"*
**作者**：Metcalf D 等
**摘要**：通过SOCS2抗体检测基因敲除小鼠模型，发现SOCS2缺陷导致STAT3信号持续活化，降低内毒素(LPS)诱导的脓毒症休克敏感性，表明SOCS2在炎症反应中通过调控STAT3发挥保护作用。
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3. **文献名称**：*"SOCS2 is a critical regulator of macrophage polarization and function"*
**作者**：Tannahill GM 等
**摘要**：研究利用SOCS2抗体进行免疫印迹和免疫荧光分析，证明SOCS2通过抑制JAK1-STAT1通路调控巨噬细胞M1/M2极化，影响其促炎/抗炎平衡，为免疫代谢疾病提供新靶点。
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**提示**：如需具体实验条件或更近期文献，建议通过PubMed或Web of Science以“SOCS2 antibody”和“应用领域(如癌症、免疫)”为关键词检索。部分抗体公司(如Abcam、CST)的产品说明书也会提供已验证的引用文献。
The Suppressor of Cytokine Signaling 2 (SOCS2) antibody is a key tool for studying the SOCS2 protein, a member of the SOCS family that regulates cytokine signaling pathways, particularly the JAK-STAT cascade. SOCS2 contains a central SH2 domain and a C-terminal SOCS-box, enabling interactions with phosphorylated tyrosine residues and E3 ubiquitin ligase components, respectively. It functions as a negative feedback regulator, targeting signaling proteins like growth hormone receptor and IGF-1 receptor for degradation via ubiquitination. Dysregulation of SOCS2 is implicated in diseases such as cancer, inflammatory disorders, and metabolic syndromes, where its expression often correlates with prognosis.
SOCS2 antibodies are widely used in research to detect protein expression and localization in tissues or cell lines via techniques like Western blot, immunohistochemistry, and flow cytometry. Specificity and validation are critical, as isoforms or homologous proteins may cross-react. Researchers often validate antibodies using knockout controls or siRNA-mediated SOCS2 silencing. Commercial antibodies vary in host species (e.g., rabbit, mouse), clonality (monoclonal/polyclonal), and epitope targets, influencing experimental outcomes. Understanding SOCS2's role in cellular homeostasis and disease mechanisms remains a focus, driving demand for reliable antibodies to advance therapeutic targeting studies.
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