| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CFC; NS1; JMML; SHP2; BPTP3; PTP2C; METCDS; PTP-1D; SH-PTP2; SH-PTP3 |
| WB Predicted band size | 68 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PTPN11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PTPN11抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *"SHP-2 tyrosine phosphatase in human diseases: mutations and clinical implications"*
**作者**: Tartaglia M, et al.
**摘要**: 该综述探讨了SHP-2(由PTPN11编码)在多种疾病中的作用，包括努南综合征和幼年粒单核细胞白血病(JMML)。文献提及使用PTPN11抗体检测突变蛋白的异常活性，并分析其与RAS/MAPK信号通路失调的关联。
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2. **文献名称**: *"Targeting SHP2 in cancers: mechanisms, biomarkers, and therapeutic potentials"*
**作者**: Chan G, et al.
**摘要**: 研究通过免疫组化(使用PTPN11抗体)和Western blot分析，揭示SHP-2在实体瘤(如乳腺癌和肺癌)中的高表达，并验证其作为治疗靶点的潜力。抗体用于评估患者样本中SHP-2的蛋白水平及定位。
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3. **文献名称**: *"Autoantibody profiling in systemic lupus erythematosus using protein microarrays: SHP-2 as a novel target"*
**作者**: Li QZ, et al.
**摘要**: 研究通过高通量蛋白质芯片筛选系统性红斑狼疮(SLE)患者的自身抗体，发现针对SHP-2的自身抗体显著升高。利用PTPN11抗体进一步验证其与疾病活动性的相关性，提示其可能参与自身免疫反应的调控。
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**备注**：以上文献为示例，实际引用时需核对数据库(如PubMed)获取准确信息。若需具体文章链接或出版年份，可进一步补充检索。
The PTPN11 antibody targets the protein encoded by the PTPN11 gene, which belongs to the protein tyrosine phosphatase (PTP) family. This gene encodes SHP-2 (Src homology region 2-containing protein tyrosine phosphatase-2), a ubiquitously expressed non-receptor phosphatase involved in regulating intracellular signaling pathways, particularly the RAS/MAPK cascade. SHP-2 plays a critical role in cell growth, differentiation, and apoptosis by modulating tyrosine phosphorylation states of signaling molecules. Mutations in PTPN11 are linked to developmental disorders such as Noonan syndrome and LEOPARD syndrome, as well as hematologic malignancies like juvenile myelomonocytic leukemia (JMML).
PTPN11 antibodies are essential tools for studying SHP-2 expression, localization, and function in both normal and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate SHP-2's role in cancer progression, immune regulation, and metabolic diseases. Some antibodies specifically detect phosphorylated or mutated forms of SHP-2. aiding in the identification of hyperactive variants associated with oncogenesis. Clinically, PTPN11 antibodies contribute to diagnostic workflows and research on targeted therapies, such as inhibitors of aberrant SHP-2 activity in mutation-driven cancers. Their application enhances understanding of tyrosine phosphatase mechanisms and potential therapeutic interventions.
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