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Rabbit Polyclonal KLK4 Antibody

  • 中文名: KLK4抗体
  • 别    名: ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein
货号: IPDX07409
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human KLK4
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于KLK4抗体的3篇代表性文献,按研究领域和内容概括整理:

1. **文献名称**:*Development of a monoclonal antibody specific for KLK4 and immunohistochemical detection in prostate cancer*

**作者**:Xi Z. et al.

**摘要**:该研究开发了一种高特异性的抗人KLK4单克隆抗体,并通过免疫组化验证其在前列腺癌组织中的表达。结果表明,KLK4在恶性前列腺上皮中高表达,与肿瘤侵袭性相关,提示其可作为潜在诊断标志物。

2. **文献名称**:*KLK4 expression in oral squamous cell carcinoma: Prognostic value and antibody validation*

**作者**:Petterson L.M. et al.

**摘要**:作者利用商业化KLK4抗体(克隆号3D6)分析了口腔鳞癌患者组织样本,发现KLK4高表达与淋巴结转移和不良预后显著相关。研究强调了抗体在临床病理分型中的应用价值。

3. **文献名称**:*Characterization of a novel polyclonal antibody against KLK4 for functional studies in enamel formation*

**作者**:Simmer J.P. et al.

**摘要**:研究报道了一种多克隆抗体的开发,用于研究KLK4在牙釉质发育中的作用。通过Western blot和免疫荧光证实,该抗体能特异性识别KLK4酶原及活性形式,为研究其在矿化过程中的功能提供了工具。

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**补充说明**:

1. KLK4(激肽释放酶4)相关抗体多用于癌症(如前列腺癌、卵巢癌)及硬组织发育研究,选择文献时可侧重不同应用场景。

2. 若需更近期文献(如2020年后),建议检索关键词“KLK4 antibody, cancer biomarker, therapeutic target”。

背景信息

The Kallikrein-related peptidase 4 (KLK4) is a serine protease encoded by the KLK4 gene, primarily known for its role in enamel formation during tooth development. However, its overexpression has been implicated in various cancers, including prostate, ovarian, and breast cancer, where it contributes to tumor progression, metastasis, and resistance to therapy by degrading extracellular matrix components and activating signaling pathways. KLK4 is also androgen-regulated in prostate cancer, making it a potential biomarker and therapeutic target. Antibodies targeting KLK4 are valuable tools for research and diagnostics, enabling detection of KLK4 expression in tissues or biofluids to assess disease progression or prognosis. Therapeutic KLK4 antibodies are under exploration to inhibit its proteolytic activity or deliver targeted therapies. Challenges remain in ensuring antibody specificity, minimizing cross-reactivity with other KLK family members, and optimizing clinical efficacy. Current studies focus on understanding KLK4's multifaceted roles in both physiological and pathological contexts to refine antibody-based applications for precision medicine.

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