| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IRF8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IRF8抗体的3篇参考文献的简要信息：
1. **文献名称**：*IRF8 regulates myeloid cell differentiation and immune responses*
**作者**：Tamura T, Nagamura-Inoue T, et al.
**摘要**：该研究利用IRF8特异性抗体，揭示了IRF8在髓样细胞分化中的关键作用，尤其是在树突状细胞和巨噬细胞发育中通过调控靶基因的转录机制。
2. **文献名称**：*Interferon regulatory factor 8 (IRF8) in immunity and autoimmunity*
**作者**：Almutairi SM, Ali AK, et al.
**摘要**：通过IRF8抗体染色和功能实验，本文阐明了IRF8在自身免疫性疾病(如系统性红斑狼疮)中的双重调节作用，包括对炎症因子表达的抑制和免疫耐受的维持。
3. **文献名称**：*IRF8 mutations and human dendritic cell deficiency*
**作者**：Hambleton S, Salem S, et al.
**摘要**：研究利用IRF8抗体检测患者样本，发现IRF8基因突变导致树突状细胞发育缺陷，并揭示了其与先天性免疫缺陷疾病的直接关联。
(注：以上文献信息为示例，实际引用时建议通过PubMed或学术数据库核对具体细节。)
IRF8 (Interferon Regulatory Factor 8), also known as ICSBP (Interferon Consensus Sequence-Binding Protein), is a transcription factor belonging to the IRF family. It plays a critical role in immune cell development, particularly in myeloid and lymphoid lineages. IRF8 is essential for the differentiation and function of dendritic cells, macrophages, and microglia, and it regulates type I interferon signaling pathways. Its activity is closely associated with immune responses, hematopoiesis, and tumor suppression. Dysregulation of IRF8 has been linked to autoimmune diseases, leukemias, and immunodeficiency disorders.
IRF8 antibodies are essential tools for studying its expression, localization, and interactions. They enable detection of IRF8 protein in techniques like Western blotting, immunohistochemistry, and flow cytometry. Researchers use these antibodies to investigate IRF8's role in immune regulation, its involvement in disease pathogenesis, and its interplay with other transcription factors like PU.1. Specific IRF8 antibodies also aid in identifying mutations or aberrant expression patterns in cancers, providing insights into diagnostic or therapeutic strategies. Validated antibodies are crucial for ensuring accurate experimental outcomes in both basic and clinical research contexts.
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