| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ANX4; PIG28; ZAP36 |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ANXA4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANXA4抗体的3篇示例参考文献(注：以下内容为模拟生成，非真实文献)：
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1. **文献名称**: *ANXA4 as a Chemoresistance Biomarker in Ovarian Cancer: Antibody Development and Clinical Validation*
**作者**: Sato, K., et al.
**摘要**: 研究通过开发高特异性ANXA4抗体，发现其在卵巢癌组织中高表达与顺铂耐药性显著相关。抗体检测可作为预测化疗反应及预后的生物标志物。
2. **文献名称**: *Targeting ANXA4 in Pancreatic Cancer Using Monoclonal Antibodies: Preclinical Studies*
**作者**: Bia, R., et al.
**摘要**: 研究团队开发了靶向ANXA4的单克隆抗体，并在胰腺癌模型中验证其抑制肿瘤转移的效果。结果显示抗体通过阻断ANXA4介导的细胞侵袭通路发挥作用。
3. **文献名称**: *ANXA4 Expression Profiling in Colorectal Cancer via Immunohistochemistry: Diagnostic Utility*
**作者**: Chen, L., & Müller, J.
**摘要**: 利用新型ANXA4抗体进行免疫组化分析，发现其在结直肠癌早期阶段表达上调，提示其作为早期诊断标志物的潜力，并与淋巴结转移风险相关。
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**说明**：以上文献聚焦ANXA4抗体在癌症诊断、治疗耐药性及靶向治疗中的应用，覆盖卵巢癌、胰腺癌、结直肠癌等不同研究场景，可供相关领域参考。如需真实文献，建议通过PubMed或Web of Science以“ANXA4 antibody”为关键词检索。
ANXA4 (Annexin A4) is a member of the annexin family of calcium-dependent phospholipid-binding proteins, which play diverse roles in membrane organization, vesicle trafficking, and cellular signaling. Expressed in various tissues, including the kidney, lung, and placenta, ANXA4 is implicated in regulating ion channel activity, exocytosis, and anti-inflammatory responses. Structurally, it contains a conserved C-terminal core domain for membrane interactions and a unique N-terminal region that modulates its functional specificity.
ANXA4 antibodies are essential tools for studying the protein's expression, localization, and biological roles. Research highlights its involvement in pathological conditions: ANXA4 overexpression is linked to chemoresistance in cancers (e.g., colorectal, ovarian), where it may promote cell survival by interacting with membrane lipids or signaling pathways like EGFR. It also shows potential as a diagnostic biomarker for certain malignancies and kidney diseases. In autoimmune contexts, ANXA4 antibodies have been detected in conditions like rheumatoid arthritis, though their pathogenic role remains unclear.
Commercial ANXA4 antibodies are typically developed using immunogenic peptides from human ANXA4 and validated via techniques like Western blot, immunohistochemistry, or immunofluorescence. Challenges include ensuring isoform specificity, as annexins share structural homology. Ongoing studies aim to clarify ANXA4's mechanistic contributions to disease and explore therapeutic targeting, such as sensitizing cancer cells to chemotherapy by inhibiting ANXA4-mediated pathways.
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