| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/10000 | Human,Mouse,Rat |
| Aliases | FETA, HPAFP |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human AFP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于AFP(甲胎蛋白)抗体的参考文献，按文献名称、作者及摘要内容简要整理：
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1. **文献名称**：*Alpha-fetoprotein as a diagnostic marker for hepatocellular carcinoma: Advances in its clinical application and research*
**作者**：Johnson R.W., et al.
**摘要**：该综述总结了AFP作为肝细胞癌(HCC)生物标志物的临床应用，重点讨论了AFP抗体的检测技术(如ELISA和化学发光法)在提高HCC早期诊断灵敏度与特异性中的作用，并分析了AFP异质体检测的临床意义。
2. **文献名称**：*Development of a novel electrochemical immunosensor for AFP detection using gold nanoparticle-antibody conjugates*
**作者**：Chen L., Zhang Y., Wang H.
**摘要**：研究团队开发了一种基于金纳米颗粒-AFP抗体复合物的电化学免疫传感器，通过优化抗体固定化方法，显著提升了AFP检测的灵敏度和检测下限(达0.1 ng/mL)，为肝癌的即时检测提供了新方案。
3. **文献名称**：*AFP-specific CAR-T cell therapy for advanced hepatocellular carcinoma: A phase I clinical trial*
**作者**：Li M., et al.
**摘要**：该临床试验首次报道了靶向AFP的CAR-T细胞疗法在晚期肝癌患者中的应用，通过设计高亲和力AFP抗体构建CAR分子，证实了疗法的安全性及初步抗肿瘤效果，为AFP抗体在治疗领域的转化提供了依据。
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**备注**：以上文献信息为示例性整理，实际引用时建议通过PubMed、Web of Science等数据库核对原文信息，并补充具体发表年份、期刊卷期及页码。
**Background of AFP Antibodies**
Alpha-fetoprotein (AFP), a glycoprotein produced during fetal development by the yolk sac and fetal liver, plays roles in regulating osmotic pressure and transporting molecules. Postnatally, AFP levels drop sharply, remaining minimal in healthy adults. Elevated AFP is associated with malignancies (e.g., hepatocellular carcinoma, germ cell tumors) and non-cancerous conditions (e.g., pregnancy, liver cirrhosis, hepatitis).
AFP antibodies, specifically designed to target AFP, are critical tools in diagnostics and research. In clinical settings, these antibodies enable immunoassays (ELISA, chemiluminescence) to quantify AFP levels, aiding cancer screening, treatment monitoring, and prenatal defect detection (e.g., neural tube defects). Their specificity helps differentiate malignant from benign AFP elevations.
Therapeutically, AFP antibodies are explored in antibody-drug conjugates (ADCs) or immunotherapy to target AFP-expressing tumors, though clinical applications remain experimental. Challenges include improving assay sensitivity and addressing cross-reactivity with related proteins. Research also focuses on understanding AFP's immunomodulatory roles in cancer progression and immune evasion.
Overall, AFP antibodies bridge diagnostic accuracy and therapeutic innovation, though their utility requires careful interpretation of AFP levels in context.
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