Rabbit Polyclonal KLK3 Antibody

Kallikrein-related peptidase 3 (KLK3), commonly known as prostate-specific antigen (PSA), is a serine protease primarily secreted by prostate epithelial cells. It plays a physiological role in semen liquefaction by cleaving seminal gel proteins. Clinically, PSA is a critical biomarker for prostate cancer (PCa) screening, diagnosis, and monitoring. Elevated serum PSA levels are associated with PCa, benign prostatic hyperplasia (BPH), and prostatitis. KLK3 antibodies are immunological tools designed to detect and quantify PSA in biological samples (e.g., blood, tissue). These antibodies, often monoclonal or polyclonal, bind to specific epitopes on PSA, enabling applications in immunoassays (ELISA, immunohistochemistry), diagnostic tests, and research. Their specificity is vital to minimize cross-reactivity with other kallikreins (e.g., KLK2) that share structural homology. In clinical diagnostics, KLK3 antibodies underpin PSA tests used for early cancer detection, risk stratification, and post-treatment surveillance (e.g., tracking recurrence after prostatectomy). However, challenges remain in distinguishing PCa from benign conditions due to PSA's limited tissue specificity. Research-grade KLK3 antibodies also facilitate studies on PSA’s role in tumor biology, metastasis, and androgen receptor signaling. Ongoing efforts focus on improving antibody sensitivity and developing novel formats (e.g., recombinant, humanized) for precision diagnostics and therapeutic targeting.