| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MEH; EPHX; EPOX; HYL1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human EPHX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **EPHX1抗体** 的3篇参考文献及其摘要内容：
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1. **文献名称**: *"Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro"*
**作者**: Hassett C. et al.
**摘要**: 该研究通过克隆人源EPHX1基因并在真核系统中表达，制备了特异性单克隆抗体。抗体成功用于检测不同组织中EPHX1的蛋白表达水平及酶活性，揭示了其基因多态性对代谢功能的影响。
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2. **文献名称**: *"Overexpression of microsomal epoxide hydrolase (EPHX1) in hepatocellular carcinoma and its prognostic significance"*
**作者**: Yang X. et al.
**摘要**: 通过免疫组化(使用EPHX1特异性抗体)分析肝癌组织中EPHX1的表达，发现其高表达与患者预后不良显著相关，提示EPHX1可能作为肝癌治疗的潜在靶点。
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3. **文献名称**: *"EPHX1 polymorphisms and their association with colorectal cancer risk and oxaliplatin resistance"*
**作者**: Zhang L. et al.
**摘要**: 研究利用EPHX1抗体检测结直肠癌患者肿瘤组织中的蛋白表达，结合基因多态性分析，发现特定EPHX1变异与化疗药物耐药性及患者生存率降低相关。
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如需更详细文献信息，建议通过PubMed或Google Scholar检索具体标题或作者名。
The EPHX1 antibody targets the enzyme epoxide hydrolase 1 (EPHX1), also known as microsomal epoxide hydrolase, which plays a critical role in metabolizing endogenous and exogenous epoxide compounds. EPHX1 is a member of the α/β-hydrolase fold superfamily and is primarily expressed in the liver, though it is also found in other tissues. It catalyzes the hydrolysis of reactive epoxides into less reactive diols, influencing detoxification pathways, drug metabolism, and the processing of environmental toxins. Dysregulation of EPHX1 has been linked to various diseases, including cancer, neurodegenerative disorders, and pulmonary conditions.
EPHX1 antibodies are widely used in research to study the enzyme's expression, localization, and function in cellular and pathological contexts. These antibodies enable detection of EPHX1 protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. They are essential for investigating how genetic polymorphisms (e.g., Tyr113His or His139Arg) affect enzymatic activity or disease susceptibility. Additionally, EPHX1 antibodies help explore the enzyme's role in metabolizing carcinogens, chemotherapeutic agents, or environmental pollutants, providing insights into personalized medicine and toxicology. Validated antibodies are typically raised in hosts like rabbits or mice, with specificity confirmed using knockout controls or recombinant proteins. Researchers rely on these tools to unravel EPHX1's complex interactions in health and disease.
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