| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | HAP; RRB2; NR1B2 |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human RARB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RARB抗体的3篇参考文献的简要信息(注：文献为模拟示例，实际引用请查询数据库)：
1. **文献名称**：*RARβ as a Biomarker for Early Detection of Epithelial Ovarian Cancer*
**作者**：Smith A, et al.
**摘要**：研究通过免疫组化(使用RARB特异性抗体)发现，RARβ在卵巢癌组织中表达显著下调，提示其可能作为卵巢癌早期诊断的生物标志物，并与肿瘤细胞分化相关。
2. **文献名称**：*Retinoic Acid Receptor Beta in Neurodegenerative Disorders*
**作者**：Chen L, et al.
**摘要**：利用RARB抗体进行Western blot和免疫荧光分析，发现阿尔茨海默病患者脑组织中RARB蛋白水平异常升高，可能通过调控神经炎症通路参与疾病进展。
3. **文献名称**：*Epigenetic Silencing of RARB in Colorectal Cancer via Promoter Methylation*
**作者**：Wang Y, et al.
**摘要**：结合甲基化测序与RARB抗体染色，证实结直肠癌中RARB启动子高甲基化导致蛋白表达缺失，且与患者预后不良显著相关。
4. **文献名称**：*RARβ Antibody Validation for Flow Cytometry Applications*
**作者**：Kim J, et al.
**摘要**：系统验证了多种RARB抗体的特异性与灵敏度，优化了流式细胞术检测方案，为血液肿瘤中RARB蛋白表达的定量分析提供可靠工具。
(提示：实际文献需通过PubMed、Web of Science等平台以“RARB antibody”或“Retinoic acid receptor beta”为关键词检索。)
**Background of RARB Antibody**
The retinoic acid receptor beta (RARβ), encoded by the *RARB* gene, belongs to the nuclear receptor superfamily and functions as a ligand-dependent transcription factor. It plays a critical role in mediating the effects of retinoic acid (RA), a derivative of vitamin A involved in cell differentiation, proliferation, and apoptosis. RARβ binds to RA response elements in DNA, regulating target genes essential for embryonic development, tissue homeostasis, and immune response. Dysregulation of RARβ has been linked to various pathologies, including cancer (e.g., breast, lung, and prostate), psoriasis, and pulmonary fibrosis, often due to epigenetic silencing or loss of heterozygosity.
RARB antibodies are immunological tools designed to detect and quantify RARβ protein expression in research and diagnostic contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study RARβ's tissue distribution, subcellular localization, and expression levels under physiological or pathological conditions. They are particularly valuable in cancer research, where RARβ is investigated as a potential tumor suppressor or biomarker for therapeutic response. Commercial RARB antibodies are typically validated for specificity against epitopes in the ligand-binding or DNA-binding domains, ensuring accurate detection across human and model organism samples.
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