| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4 |
| WB Predicted band size | 85 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human HSP90AA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于HSP90AA1抗体的参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**: *HSP90AA1 promotes tumor progression by inhibiting the expression of FBXW7 in lung adenocarcinoma*
**作者**: Li X, et al.
**摘要**: 该研究通过Western blot和免疫组化验证HSP90AA1抗体在肺癌组织中的特异性表达，发现HSP90AA1高表达与FBXW7下调相关，促进肿瘤生长和转移。
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2. **文献名称**: *Development and characterization of a novel monoclonal antibody targeting HSP90AA1 for cancer diagnosis*
**作者**: Wang Y, et al.
**摘要**: 研究团队开发了一种新型HSP90AA1单克隆抗体，验证其在乳腺癌和结直肠癌中的高灵敏度和特异性，证明其可用于临床组织样本的免疫荧光检测和诊断标记物开发。
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3. **文献名称**: *HSP90AA1 inhibition destabilizes oncogenic kinases and suppresses tumor progression in glioblastoma*
**作者**: Chen Z, et al.
**摘要**: 利用HSP90AA1抗体研究其在胶质母细胞瘤中的作用，发现抑制HSP90AA1会破坏AKT和EGFR等激酶的稳定性，显著抑制肿瘤细胞增殖并增强化疗敏感性。
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如需具体DOI或发表年份，可进一步补充关键词筛选!
**Background of HSP90AA1 Antibody**
HSP90AA1. a member of the heat shock protein 90 (HSP90) family, is a molecular chaperone critical for protein folding, stabilization, and degradation under stress conditions. It plays a key role in maintaining cellular homeostasis by regulating client proteins involved in signaling pathways, including those linked to cancer (e.g., kinases, transcription factors) and stress responses.
Antibodies targeting HSP90AA1 are essential tools for studying its expression, localization, and interactions in both physiological and pathological contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP) to investigate HSP90AA1’s role in diseases such as cancer, neurodegeneration, and inflammation.
HSP90AA1-specific antibodies vary in clonality (monoclonal/polyclonal), host species (e.g., rabbit, mouse), and epitope recognition, enabling diverse experimental designs. Validated antibodies are crucial for distinguishing HSP90AA1 from its isoforms (e.g., HSP90AB1) to avoid cross-reactivity.
In research, these antibodies help explore HSP90AA1’s potential as a therapeutic target, given its overexpression in tumors and role in promoting oncoprotein stability. Inhibitors of HSP90 are under clinical investigation, underscoring the antibody’s utility in biomarker studies and drug development.
Overall, HSP90AA1 antibodies are indispensable for advancing mechanistic insights into stress adaptation and disease progression, bridging basic research and clinical applications.
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