Rabbit Polyclonal YWHAH Antibody

The YWHAH antibody is a crucial tool in studying the 14-3-3 protein family, specifically targeting the 14-3-3η (eta) isoform encoded by the YWHAH gene. This conserved protein family regulates diverse cellular processes, including signal transduction, cell cycle control, apoptosis, and stress responses by binding to phosphorylated serine/threonine residues on client proteins. YWHAH antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to detect 14-3-3η expression, localization, and interactions in tissues or cultured cells. Research highlights its role in neurological disorders (e.g., Alzheimer’s disease, Creutzfeldt-Jakob disease) and cancer, where dysregulated 14-3-3η may influence tumor progression or neurodegeneration via abnormal protein aggregation. Commercial YWHAH antibodies are typically validated for specificity across human, mouse, and rat models, though cross-reactivity with other 14-3-3 isoforms (e.g., β, γ) requires careful experimental controls. Recent studies also explore its involvement in immune regulation and metabolic pathways, underscoring its multifaceted biological significance. Quality-controlled batches ensure reproducibility, supporting both diagnostic research and therapeutic target discovery.