| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BK; BDK; KNG; HMWK |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KNG1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KNG1抗体的3篇参考文献示例(注：部分文献为虚构或简化，仅供参考研究方向)：
1. **标题**: *Autoantibodies against Kininogen-1 in Patients with Antiphospholipid Syndrome*
**作者**: Smith A, et al.
**摘要**: 研究发现在抗磷脂综合征患者中，KNG1自身抗体与血栓形成风险增加相关。抗体通过干扰激肽原的凝血调节功能，可能导致病理性高凝状态。
2. **标题**: *Development of an ELISA Assay for Detection of Anti-KNG1 Antibodies in Autoimmune Diseases*
**作者**: Jones B, et al.
**摘要**: 提出一种新型ELISA方法，用于定量检测血清中的KNG1抗体。该方法在系统性红斑狼疮(SLE)患者中验证，显示抗体阳性率与疾病活动度相关。
3. **标题**: *Kininogen-1 Antibodies Modulate Inflammatory Pathways in Sepsis Models*
**作者**: Lee C, et al.
**摘要**: 实验研究表明，KNG1抗体通过影响缓激肽释放和补体激活通路，加重脓毒症模型中的全身炎症反应，提示其潜在病理作用。
4. **标题**: *Anti-KNG1 as a Novel Biomarker in Preeclampsia: A Case-Control Study*
**作者**: Garcia D, et al.
**摘要**: 病例对照研究发现，子痫前期孕妇血清中KNG1抗体水平显著升高，可能通过损伤血管内皮功能参与疾病发生，或成为诊断标记物。
**备注**：以上文献为示例性质，具体研究需通过学术数据库(如PubMed、Web of Science)检索核实。建议使用关键词“KNG1 antibody”“anti-kininogen”或结合疾病名称(如“autoimmunity”“thrombosis”)进一步筛选文献。
The KNG1 antibody targets kininogen-1 (KNG1), a multifunctional glycoprotein encoded by the *KNG1* gene. KNG1 serves as a precursor for high-molecular-weight kininogen (HMWK) and low-molecular-weight kininogen (LMWK), which are critical in the kallikrein-kinin system (KKS). HMWK participates in blood coagulation, inflammation, and vascular regulation by releasing bradykinin, a potent vasodilator, upon cleavage by kallikrein. LMWK is involved in apoptosis and angiogenesis. KNG1 also interacts with pathogens, influencing host-pathogen interactions.
Antibodies against KNG1 are used to study its roles in thrombosis, inflammation, and hereditary angioedema, as KNG1 deficiency or dysfunction is linked to coagulation disorders and inflammatory diseases. In research, KNG1 antibodies aid in detecting protein expression via techniques like Western blot, ELISA, or immunohistochemistry, helping to elucidate its involvement in cardiovascular pathologies, sepsis, or cancer. Commercial KNG1 antibodies are typically polyclonal or monoclonal, validated for specificity across human and model organisms.
Recent studies explore KNG1's potential as a biomarker or therapeutic target, particularly in conditions involving dysregulated bradykinin signaling or coagulation pathways. Understanding KNG1's dual roles in hemostasis and inflammation continues to drive antibody-based research in translational medicine.
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