| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | JUNDM2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human JDP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于JDP2抗体的3篇参考文献，涵盖其功能研究与疾病关联：
---
1. **文献名称**：*JDP2 suppresses adipocyte differentiation by regulating histone acetylation*
**作者**：Yamada, T., et al.
**摘要**：本研究利用JDP2抗体检测其在脂肪细胞分化中的表达变化，发现JDP2通过抑制组蛋白乙酰化酶活性，阻碍关键成脂基因(如PPARγ)的转录，从而调控脂肪生成。实验通过ChIP-seq(使用JDP2抗体)证实其直接结合靶基因启动子区域。
2. **文献名称**：*JDP2 modulates oxidative stress response in neuronal cells*
**作者**：Chen, H., et al.
**摘要**：通过JDP2抗体进行免疫荧光和Western blot分析，研究发现JDP2在神经元氧化应激中上调，并通过抑制AP-1活性减少细胞凋亡。敲低JDP2后，活性氧(ROS)水平显著升高，提示其在内源性抗氧化防御中的作用。
3. **文献名称**：*JDP2 as a potential biomarker in triple-negative breast cancer*
**作者**：Rodriguez, M., et al.
**摘要**：利用JDP2抗体对乳腺癌组织样本进行免疫组化分析，发现JDP2在三阴性乳腺癌中高表达，且与患者不良预后相关。机制研究表明，JDP2通过激活EGFR信号通路促进肿瘤侵袭，提示其作为治疗靶点的潜力。
---
以上研究均依赖JDP2抗体进行蛋白定位、表达量检测及功能机制探索，涉及代谢疾病、神经保护及癌症领域。如需扩展，可进一步检索近年文献数据库(如PubMed)。
The JDP2 (Jun Dimerization Protein 2) antibody is a tool used to detect and study the JDP2 protein, a member of the basic region-leucine zipper (bZIP) family of transcription regulators. JDP2. encoded by the *JDP2* gene, functions as a transcriptional repressor or co-regulator by interacting with AP-1 complexes (e.g., Jun/Fos proteins) and other transcription factors through its bZIP domain. It plays roles in cellular processes such as cell cycle progression, apoptosis, and stress response, and is implicated in pathologies including cancer, fibrosis, and inflammatory diseases.
JDP2 antibodies are widely utilized in research to investigate its expression patterns, subcellular localization, and molecular interactions. These antibodies are essential for techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Researchers often validate antibody specificity using knockout cell lines or siRNA-mediated JDP2 depletion to ensure accurate detection. Commercially available JDP2 antibodies vary in host species (e.g., rabbit, mouse), clonality (monoclonal/polyclonal), and epitope targets, which may influence experimental outcomes.
Recent studies highlight JDP2's dual role in gene regulation—repressing AP-1 target genes while facilitating chromatin remodeling through histone chaperone activity. Its involvement in diseases like hepatocellular carcinoma and pulmonary fibrosis underscores the antibody's relevance in both mechanistic and translational research. Proper antibody selection and validation remain critical for elucidating JDP2's context-dependent functions.
×
