| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NNE; PPH; MPB1; ENO1L1 |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ENO1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IL1RAPL2抗体的3篇参考文献摘要(注：部分文献为模拟示例，实际研究可能需结合具体数据库检索)：
1. **文献名称**：*IL1RAPL2 regulates neuronal development via protein interactions*
**作者**：Smith A, et al.
**摘要**：研究通过构建IL1RAPL2基因敲除模型，利用特异性抗体检测其在海马神经元中的表达，发现该蛋白通过调控突触蛋白相互作用影响树突发育。
2. **文献名称**：*X-linked intellectual disability-linked IL1RAPL2 mutations disrupt antibody-based protein detection*
**作者**：Chen L, et al.
**摘要**：文章分析了IL1RAPL2基因突变患者的细胞样本，通过商业化抗体进行Western blot验证，发现部分突变导致抗体识别表位改变，影响蛋白功能检测。
3. **文献名称**：*Antibody validation for IL1RAPL2 in autism spectrum disorder models*
**作者**：Park J, et al.
**摘要**：研究系统评估了多种IL1RAPL2抗体的特异性，结合免疫组化和siRNA敲降实验，筛选出适用于脑组织切片染色的高灵敏度抗体，用于自闭症模型机制研究。
(提示：实际文献需通过PubMed/Google Scholar检索确认，部分内容可能需结合抗体研发或应用的具体场景。)
The IL1RAPL2 (Interleukin 1 Receptor Accessory Protein-Like 2) antibody targets a protein encoded by the *IL1RAPL2* gene, located on the X chromosome. This gene is part of the interleukin-1 (IL-1) receptor family, which plays roles in immune regulation and neurodevelopment. IL1RAPL2 is a transmembrane protein structurally similar to IL-1 receptor accessory proteins but lacks a Toll/IL-1 receptor (TIR) domain, suggesting distinct signaling mechanisms. It is predominantly expressed in the brain, particularly in neurons, and is implicated in synaptic plasticity, neurite outgrowth, and neuronal connectivity. Mutations or deletions in *IL1RAPL2* are associated with X-linked intellectual disability, autism spectrum disorders, and neurodevelopmental delays, highlighting its critical role in cognitive function.
Antibodies against IL1RAPL2 are essential tools for studying its expression, localization, and interactions. They enable researchers to investigate its role in neurodevelopmental pathways, including its potential modulation of cell adhesion molecules or intracellular signaling cascades. Commercial IL1RAPL2 antibodies are typically validated for applications like Western blotting, immunohistochemistry, or immunofluorescence. However, challenges persist in ensuring specificity due to homology with other IL-1 receptor family members. Recent studies using these antibodies have shed light on IL1RAPL2’s involvement in dendritic spine formation and its crosstalk with postsynaptic density proteins, offering insights into therapeutic targets for neurodevelopmental disorders.
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