| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ATP1A1; Sodium/potassium-transporting ATPase subunit alpha-1; Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1 |
| Entrez GeneID | 24211 |
| WB Predicted band size | Calculated MW: 113 kDa; Observed MW: 113 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from rat ATP1 alpha1/Na+K+ ATPase1 around the phosphorylation site of Ser23. AA range:15-64 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是基于现有文献的模拟示例，由于HNRNPA1L2研究较为小众，实际文献可能有限。建议通过PubMed或Google Scholar以关键词“HNRNPA1L2 antibody”进一步检索最新进展：
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1. **文献名称**: "HNRNPA1L2 as a novel biomarker in hepatocellular carcinoma: Expression analysis using a specific polyclonal antibody"
**作者**: Zhang Y, et al.
**摘要**: 本研究开发了一种针对HNRNPA1L2的多克隆抗体，并通过免疫组化和Western blot验证其在肝癌组织中的高表达，提示其作为潜在诊断标志物的可能性。
2. **文献名称**: "Role of HNRNPA1L2 in mRNA splicing regulation: Insights from antibody-mediated knockdown experiments"
**作者**: Lee S, Kim JH.
**摘要**: 利用特异性抗体阻断HNRNPA1L2的RNA结合功能，发现其调控多种前体mRNA的剪接过程，影响细胞周期相关基因表达。
3. **文献名称**: "Commercial antibody validation for HNRNPA1L2: A comparative study across multiple cancer cell lines"
**作者**: Smith R, et al.
**摘要**: 评估了市售HNRNPA1L2单克隆抗体的特异性，发现部分抗体存在交叉反应性，强调验证抗体在特定实验模型中的必要性。
4. **文献名称**: "HNRNPA1L2 aggregation in neurodegenerative diseases: Immunohistochemical detection with a novel antibody"
**作者**: Patel K, et al.
**摘要**: 开发了一种高灵敏度抗体用于检测HNRNPA1L2在阿尔茨海默病患者脑组织中的异常聚集，探讨其与tau蛋白病理的相关性。
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**注意**：上述内容为模拟生成，实际文献需通过学术数据库核实。若需具体文章，建议访问PubMed(https://pubmed.ncbi.nlm.nih.gov)并搜索“HNRNPA1L2 antibody”获取最新结果。
The HNRNPA1L2 antibody is a tool used to study the heterogeneous nuclear ribonucleoprotein A1-like 2 (HNRNPA1L2), a member of the HNRNP family involved in RNA metabolism. HNRNPA1L2 shares structural homology with HNRNPA1. including RNA-binding domains critical for pre-mRNA processing, splicing, and transport. While its exact biological role remains under investigation, HNRNPA1L2 is hypothesized to regulate gene expression by interacting with RNA transcripts or participating in stress granule dynamics.
This antibody is primarily utilized in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect HNRNPA1L2 expression and localization in cells or tissues. Studies suggest potential links between HNRNPA1L2 dysregulation and diseases, including neurodegenerative disorders or cancers, where RNA processing errors are implicated. However, its clinical significance is less established compared to well-characterized HNRNP proteins like HNRNPA1 or HNRNPA2B1.
Commercial HNRNPA1L2 antibodies are typically validated for specificity, given the high sequence similarity among HNRNP family members. Researchers employ these reagents to explore its role in cellular stress responses, viral infection pathways, or as a biomarker in disease models. Further work is needed to clarify its mechanistic contributions and therapeutic relevance.
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