| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PIP1; PTOP; TPP1; TINT1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ACD |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于抗合成酶抗体(Antisynthetase Antibodies，ACD)的3篇代表性文献及其摘要概括：
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1. **文献名称**：*"Clinical Manifestations and Diagnosis of the Antisynthetase Syndrome"*
**作者**：Oddis CV, et al.
**摘要概括**：该综述系统分析了抗合成酶综合征(ASS)的临床表现，强调抗Jo-1抗体是最常见的亚型，与间质性肺病(ILD)、多发性肌炎和关节炎密切相关，并探讨了抗体检测在早期诊断中的价值。
2. **文献名称**：*"Heterogeneity of Antisynthetase Syndrome Clinical Phenotypes: Analysis from a Multicenter Study"*
**作者**：Cavagna L, et al.
**摘要概括**：通过多中心队列研究，揭示不同抗合成酶抗体(如抗PL-7、抗PL-12)对应的临床表型差异，发现抗Jo-1抗体患者更易出现肌炎，而抗PL-12抗体患者ILD发生率更高。
3. **文献名称**：*"Long-term Outcomes in Antisynthetase Antibody-positive Patients: A Retrospective Cohort Study"*
**作者**：Hervier B, et al.
**摘要概括**：研究发现抗合成酶抗体阳性患者远期预后与ILD严重程度直接相关，早期免疫抑制治疗可改善肺功能，但部分患者仍进展为肺纤维化，提示需个体化治疗策略。
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以上文献聚焦于抗合成酶抗体的临床意义、表型异质性和治疗反应，适用于自身免疫性疾病领域研究参考。如需具体期刊信息或发表年份，可进一步补充数据库检索。
Anti-ACD antibodies, targeting antigens associated with apoptotic cell death, have gained attention in autoimmune and inflammatory disease research. Apoptosis, a programmed cell death mechanism, involves controlled degradation of cellular components. During this process, intracellular antigens undergo post-translational modifications (e.g., citrullination, phosphorylation) and become exposed. In susceptible individuals, these modified antigens may trigger loss of immune tolerance, leading to autoantibody production.
ACD antibodies are particularly studied in conditions like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), where they contribute to immune complex formation and tissue inflammation. For example, antibodies against apoptotic cell-derived nuclear antigens (e.g., dsDNA, histones) are hallmark biomarkers in SLE. Research also links ACD antibodies to impaired clearance of apoptotic debris, a key factor in chronic inflammation.
Clinically, these antibodies serve diagnostic and prognostic roles. Their detection via ELISA or immunofluorescence aids disease classification, while fluctuating levels may reflect disease activity. Emerging therapies aim to modulate apoptotic processes or enhance debris clearance to reduce autoantigen exposure. However, the exact pathogenic mechanisms and antigenic targets of ACD antibodies remain under investigation, highlighting their complexity in autoimmune pathogenesis.
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