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Rabbit Polyclonal NSD2 Antibody

  • 中文名: NSD2抗体
  • 别    名: WHS; TRX5; KMT3F; KMT3G; MMSET; RAUST; WHSC1; REIIBP
货号: IPDX05997
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesEDSC
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human COL5A2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于NSD2抗体的3篇参考文献示例(基于公开信息概括,非真实文献,仅供格式参考):

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1. **文献名称**:*NSD2-mediated histone H3 lysine 36 dimethylation regulates cancer cell proliferation and invasion*

**作者**:Li Y, Zhang W, et al.

**摘要**:本研究利用NSD2特异性抗体,通过ChIP-seq和免疫印迹技术,揭示了NSD2在多种癌症中通过催化H3K36me2修饰促进肿瘤细胞增殖和转移的机制。

2. **文献名称**:*Development and validation of a monoclonal antibody targeting the catalytic domain of NSD2*

**作者**:Smith J, Brown K, et al.

**摘要**:文章报道了一种新型NSD2单克隆抗体的开发与验证,证明其可特异性识别NSD2蛋白的SET结构域,并成功应用于免疫组化检测多发性骨髓瘤样本中的NSD2异常表达。

3. **文献名称**:*NSD2 interacts with BRD4 to drive oncogenic transcriptional programs in leukemia*

**作者**:Chen X, Wang H, et al.

**摘要**:通过免疫共沉淀(Co-IP)结合NSD2抗体,研究发现NSD2与BRD4在白血病细胞中形成复合物,协同调控致癌基因表达,为靶向表观遗传治疗提供了新思路。

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如需真实文献,建议检索PubMed或Google Scholar,关键词:**NSD2 antibody**, **EHMT1**, **H3K36me2**。

背景信息

The NSD2 antibody is a research tool designed to detect and study the nuclear receptor-binding SET domain-containing protein 2 (NSD2), also known as WHSC1 or MMSET. NSD2 is a histone methyltransferase that primarily catalyzes the dimethylation of histone H3 at lysine 36 (H3K36me2), playing a critical role in epigenetic regulation of gene expression. It is involved in chromatin remodeling, transcriptional elongation, and DNA repair. Dysregulation of NSD2 has been linked to several diseases, most notably cancer. For instance, NSD2 overexpression or activating mutations are associated with hematological malignancies, including multiple myeloma, where t(4;14) chromosomal translocation leads to its aberrant expression. Additionally, NSD2 mutations are implicated in developmental disorders such as Wolf-Hirschhorn syndrome.

The NSD2 antibody is widely used in molecular biology and clinical research to investigate NSD2's expression patterns, interactions, and functional mechanisms. It aids in applications like Western blotting, immunohistochemistry, ChIP-seq, and fluorescence microscopy. Researchers utilize this antibody to explore NSD2's oncogenic roles, its impact on epigenetic landscapes, and its potential as a therapeutic target. Validating antibody specificity through knockout controls or siRNA-based approaches is essential to ensure accurate experimental outcomes. As NSD2 continues to emerge as a key player in epigenetics and disease, its corresponding antibody remains a vital reagent for advancing both basic and translational studies.

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