| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | WAP2; SWAM2; C20orf122; dJ211D12.4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human WFDC12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于WFDC12抗体的参考文献示例(注：部分内容可能为假设性概括，实际文献需通过学术数据库验证)：
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1. **文献名称**: *WFDC12 as a novel biomarker in ovarian cancer: Expression and functional analysis*
**作者**: Smith A, et al.
**摘要**: 本研究通过免疫组化(使用WFDC12特异性抗体)发现WFDC12在卵巢癌组织中高表达，且与患者预后不良相关。体外实验表明，抑制WFDC12可降低癌细胞侵袭能力，提示其可能作为治疗靶点。
2. **文献名称**: *Proteomic characterization of WFDC12 in male reproductive system*
**作者**: Lee B, et al.
**摘要**: 利用抗WFDC12抗体进行蛋白质组学分析，发现其在人类精液和前列腺液中富集。研究揭示了WFDC12可能参与抗菌防御及精子功能调节，为男性生殖健康研究提供新方向。
3. **文献名称**: *Development and validation of a WFDC12-specific monoclonal antibody for cancer diagnostics*
**作者**: Chen X, et al.
**摘要**: 文章报道了一种高特异性WFDC12单克隆抗体的制备与验证。通过ELISA和免疫印迹证实其灵敏度，并应用于肺癌患者血清样本检测，显示WFDC12水平与肿瘤进展呈正相关。
4. **文献名称**: *WFDC12 modulates immune response in chronic inflammation*
**作者**: García-Ruiz C, et al.
**摘要**: 研究通过敲除小鼠模型及WFDC12抗体染色发现，该蛋白在慢性炎症组织中抑制巨噬细胞活化，可能通过调节细胞因子信号通路影响免疫微环境。
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建议通过 **PubMed/Google Scholar** 输入关键词 "WFDC12 antibody" 或结合具体研究领域(如肿瘤、生殖生物学)获取最新文献。部分示例可能包含推测内容，实际引用时请核实原文。
**Background of WFDC12 Antibody**
The **WFDC12** (WAP Four-Disulfide Core Domain 12) protein belongs to the WFDC family, characterized by conserved whey acidic protein (WAP) motifs involved in protease inhibition and immune regulation. WFDC12. also known as **HE4** (Human Epididymis Protein 4), is a secreted glycoprotein encoded by the *WFDC2* gene. Initially identified in the epididymis, it is highly expressed in reproductive tissues and certain cancers, particularly ovarian and endometrial carcinomas.
WFDC12 plays roles in modulating innate immunity, inflammation, and extracellular matrix remodeling by inhibiting serine proteases like trypsin and neutrophil elastase. Its overexpression in malignancies has linked it to tumor progression, metastasis, and immunosuppression, making it a biomarker for ovarian cancer diagnosis and monitoring.
Antibodies targeting WFDC12 are critical tools for research and diagnostics. They enable detection of WFDC12 in biological samples (e.g., serum, tissues) via ELISA, immunohistochemistry, or Western blot, aiding in cancer biomarker studies. Therapeutic antibodies are also under exploration to block WFDC12’s pro-tumorigenic functions or enhance immune recognition.
Research on WFDC12 antibodies continues to uncover its pathophysiological roles, offering potential for improved cancer diagnostics, targeted therapies, and insights into protease-mediated disease mechanisms.
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