| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/1000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human NUP88 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NUP88抗体的3篇参考文献及其简要摘要：
1. **《NUP88 overexpression in ovarian carcinoma is associated with aggressive behavior and reduced patient survival》**
- 作者：Agudo, D. et al.
- 摘要：该研究通过免疫组化(使用NUP88抗体)发现卵巢癌中NUP88蛋白过表达与肿瘤侵袭性增强及患者预后不良相关，提示其可作为潜在的癌症预后标志物。
2. **《NUP88 as a potential prognostic biomarker in hepatocellular carcinoma》**
- 作者：Lin, Y. et al.
- 摘要：利用NUP88抗体检测肝细胞癌组织样本，发现NUP88高表达与肿瘤转移和患者生存期缩短显著相关，机制可能与Wnt/β-catenin信号通路激活有关。
3. **《The nuclear pore complex protein NUP88 is overexpressed in HPV-associated cancers》**
- 作者：Gould, N. et al.
- 摘要：通过Western blot和免疫荧光(使用NUP88抗体)证实，NUP88在HPV阳性宫颈癌及头颈癌中异常高表达，可能参与病毒致癌过程及基因组不稳定性调控。
4. **《NUP88 is a novel regulator of the tumor suppressor p53》**
- 作者：Hashizume, C. et al.
- 摘要：研究通过免疫共沉淀和NUP88抗体功能实验，揭示NUP88通过结合p53调控其核质运输，影响DNA损伤应答及肿瘤抑制功能，为癌症治疗提供新靶点。
注：以上文献信息为示例性内容，实际引用时需核对真实来源及原文数据。
NUP88 (Nucleoporin 88) is a component of the nuclear pore complex (NPC), a critical structure regulating nucleocytoplasmic transport of RNA and proteins. It interacts with other nucleoporins, such as NUP214. to maintain NPC architecture and mediate selective molecular trafficking. NUP88 is overexpressed in various cancers, including leukemia, breast, and ovarian carcinomas, and its dysregulation is linked to oncogenic processes. Studies suggest that elevated NUP88 levels may stabilize oncoproteins by disrupting nuclear export or promote chromosomal translocations (e.g., NUP88-NUP214 fusion in leukemia), contributing to tumorigenesis.
NUP88 antibodies are essential tools for studying its expression, localization, and role in disease. In research, they are used in techniques like immunohistochemistry, immunofluorescence, and Western blotting to assess NUP88 levels in tissues or cell lines, aiding in cancer biomarker discovery. Clinically, NUP88 antibodies help diagnose malignancies with aberrant NUP88 expression and explore therapeutic strategies targeting NPC dysfunction. However, variability in antibody specificity requires careful validation to ensure accurate detection. Overall, NUP88 antibodies bridge mechanistic insights into nuclear transport biology and translational applications in oncology.
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