| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/35-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MEF2BNB |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human BORCS8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BORCS8抗体的虚构示例参考文献(基于公开领域知识框架，非真实文献)：
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1. **文献名称**: *BORCS8 Antibody Characterization in Lysosomal Regulation*
**作者**: Johnson A, et al.
**摘要**: 研究报道了一种特异性识别BORCS8蛋白的单克隆抗体，验证了其在溶酶体膜蛋白复合体(BLOC-1)中的表达定位，并发现BORCS8敲低导致溶酶体功能异常，提示其参与神经退行性疾病的潜在机制。
2. **文献名称**: *BORCS8 as a Biomarker in Alzheimer's Disease Models*
**作者**: Smith R, et al.
**摘要**: 通过BORCS8抗体检测阿尔茨海默病小鼠模型脑组织，发现BORCS8蛋白水平与β-淀粉样蛋白沉积呈负相关，表明其在溶酶体清除途径中可能发挥保护作用。
3. **文献名称**: *Development of a Polyclonal BORCS8 Antibody for Functional Studies*
**作者**: Lee M, et al.
**摘要**: 描述了兔源多克隆抗体的开发，通过免疫印迹和免疫荧光验证其特异性，并用于研究BORCS8与自噬相关蛋白的相互作用，揭示其在细胞稳态中的调控网络。
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**备注**：以上为模拟文献，实际研究中请通过PubMed或SciHub等平台检索真实文献。BORCS8相关研究多集中于溶酶体调控、神经退行性疾病及BLOC-1复合体功能领域。
The BORCS8 antibody targets the BORCS8 protein, a component of the BLOC-1-related complex (BORC), which plays a critical role in lysosome positioning and trafficking. BORC, discovered in 2015. is an evolutionarily conserved multiprotein complex that regulates lysosome distribution by recruiting the small GTPase Arl8b to lysosomal membranes, facilitating their movement along microtubules. BORCS8 (also known as C17orf59 or BLOS1) is one of eight subunits within BORC, and its function is tightly linked to lysosome-mediated cellular processes, including autophagy, nutrient sensing, and organelle degradation.
Antibodies against BORCS8 are primarily used in research to study lysosome dynamics, intracellular trafficking pathways, and disorders associated with lysosomal dysfunction, such as neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) and cancers. These antibodies enable techniques like Western blotting, immunofluorescence, and immunoprecipitation to visualize BORCS8 expression, localization, and interactions.
Recent studies highlight BORCS8’s role in neuronal health, where lysosomal misregulation contributes to pathology. Its involvement in cancer cell invasion and metastasis is also under investigation. The development and validation of BORCS8 antibodies have advanced understanding of lysosome biology, offering potential therapeutic insights for lysosome-related diseases. However, specificity and cross-reactivity challenges require careful validation when using these reagents experimentally.
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