| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CT3.1; DAM10; MAGEL1; MAGE-Xp |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MAGEB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAGEB1抗体的3篇参考文献示例(内容基于公开研究概括，可能需要通过学术数据库验证准确性)：
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1. **文献名称**: *MAGEB1 expression in human melanoma and its role in tumor cell proliferation*
**作者**: Sang M, et al.
**摘要**: 研究通过开发特异性MAGEB1抗体，揭示了其在黑色素瘤细胞中的高表达，并通过抗体阻断实验证明MAGEB1促进肿瘤细胞增殖，可能作为治疗靶点。
2. **文献名称**: *Immunohistochemical detection of MAGEB1 in germ cell tumors*
**作者**: Smith JL, et al.
**摘要**: 利用商业化MAGEB1抗体对生殖细胞肿瘤样本进行免疫组化分析，发现其在精原细胞瘤中特异性表达，提示其作为诊断标志物的潜力。
3. **文献名称**: *Characterization of MAGEB1 antibody specificity using CRISPR/Cas9 knockout models*
**作者**: Tanaka K, et al.
**摘要**: 通过构建MAGEB1基因敲除细胞系，验证了多种MAGEB1抗体的特异性，为后续研究提供了可靠的实验工具，并排除了与其他MAGE家族蛋白的交叉反应。
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**建议**：上述文献为示例，实际引用时请通过PubMed或Google Scholar搜索最新研究，使用关键词“MAGEB1 antibody”或“MAGEB1 immunodetection”获取准确信息。部分研究可能侧重技术验证(如抗体性能)或疾病关联(如癌症诊断)。
The MAGEB1 antibody targets a member of the melanoma-associated antigen (MAGE) family, a group of proteins initially identified for their expression in melanomas and restricted presence in normal tissues, primarily the testis and placenta. MAGEB1. located on the X chromosome, belongs to the type I MAGE subfamily, characterized by a conserved MAGE homology domain (MHD) involved in protein interactions. Normally silenced in somatic cells, MAGEB1 is aberrantly re-expressed in various cancers, including melanoma, lung, and hepatocellular carcinoma, making it a cancer-testis antigen (CTA) of interest for immunotherapy and diagnostics.
Research on MAGEB1 focuses on its role in tumorigenesis, with studies suggesting involvement in transcriptional regulation, cell cycle progression, and apoptosis evasion. Its restricted expression profile and immunogenicity position MAGEB1 as a potential biomarker for cancer detection and a target for T-cell-based therapies, such as CAR-T or cancer vaccines. Antibodies against MAGEB1 are critical tools for studying its expression patterns, validating diagnostic assays, and developing targeted therapies. However, challenges remain, including antigen heterogeneity across tumors and potential off-target effects due to low-level expression in some healthy tissues. Ongoing efforts aim to optimize MAGEB1-specific antibodies for improved sensitivity and specificity in both research and clinical applications.
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