Rabbit Polyclonal STK11 Antibody

The STK11 antibody is a crucial tool in studying the serine/threonine kinase 11 (STK11) protein, also known as liver kinase B1 (LKB1). STK11 is a tumor suppressor gene that regulates cell polarity, metabolism, and proliferation through signaling pathways like AMPK/mTOR. Mutations in STK11 are linked to Peutz-Jeghers syndrome, a hereditary condition causing gastrointestinal polyps and increased cancer risk, as well as sporadic cancers such as lung adenocarcinoma and cervical cancer. Antibodies targeting STK11 enable researchers to detect protein expression, localization, and post-translational modifications in tissues or cell lines via techniques like immunohistochemistry (IHC), Western blotting, or immunofluorescence. These antibodies are vital for investigating STK11's role in tumor suppression, metabolic regulation, and response to therapies like mTOR inhibitors. Clinically, STK11 status is increasingly recognized as a biomarker for predicting therapeutic outcomes and disease progression, particularly in non-small cell lung cancer. However, antibody specificity and validation remain critical due to potential cross-reactivity with other kinases or isoforms. Ongoing research focuses on understanding how STK11 loss drives tumorigenesis and influences immune microenvironment interactions, underscoring its importance in both basic and translational oncology.