| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | APT2; PSF2; ABC18; ABCB3; PSF-2; RING11; D6S217E |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human TAP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TAP2抗体的3篇参考文献的简要信息：
1. **文献名称**：*"Defective expression of transporter in antigen processing 1 (TAP1) in human cancers"*
**作者**：Seliger, B., et al.
**摘要**：该研究分析了多种肿瘤细胞中TAP1和TAP2的表达缺陷，发现TAP2的异常表达与MHC I类分子抗原呈递功能受损相关，并通过抗体检测证实了其在肿瘤免疫逃逸中的作用。
2. **文献名称**：*"MHC class I antigen processing and presentation: pathways and challenges"*
**作者**：Neefjes, J., et al.
**摘要**：综述了MHC I类分子抗原呈递的分子机制，重点讨论了TAP1/TAP2异二聚体在肽转运中的功能，并利用特异性抗体揭示了其在病毒感染和癌症中的调控异常。
3. **文献名称**：*"Autoantibodies to TAP2 in rheumatoid arthritis patients"*
**作者**：Ritz, U., et al.
**摘要**：研究发现类风湿性关节炎患者血清中存在针对TAP2的自身抗体，通过免疫印迹和ELISA验证，提示TAP2自身免疫反应可能参与疾病病理机制。
4. **文献名称**：*"Structure and function of the TAP2 transmembrane domain in antigen peptide transport"*
**作者**：Abele, R., & Tampé, R.
**摘要**：通过抗体验证和结构生物学手段，解析了TAP2的跨膜结构域在抗原肽转运中的关键作用，揭示了其突变对MHC I类分子组装的影响。
(注：以上文献信息为示例性概括，实际引用时需核对原始文献及发表年份。)
The TAP2 (Transporter Associated with Antigen Processing 2) protein is a critical component of the major histocompatibility complex (MHC) class I antigen presentation pathway. It forms a heterodimeric complex with TAP1. functioning as an ATP-binding cassette (ABC) transporter located in the endoplasmic reticulum (ER) membrane. Together, TAP1 and TAP2 mediate the translocation of cytosolic antigenic peptides into the ER lumen, where they bind to MHC class I molecules for subsequent presentation to CD8+ T cells, enabling immune surveillance of infected or cancerous cells.
Antibodies targeting TAP2 are essential tools for studying its expression, localization, and functional interactions. They are widely used in techniques like Western blotting, immunofluorescence, and flow cytometry to investigate TAP2 regulation under pathological conditions, such as viral immune evasion (e.g., herpesviruses downregulate TAP2 to inhibit antigen presentation) or autoimmune disorders. Mutations in the TAP2 gene are linked to bare lymphocyte syndrome type I (MHC class I deficiency), characterized by recurrent infections. Research using TAP2 antibodies has also explored its role in cancer immunology, as dysregulated antigen presentation may contribute to tumor immune escape. These studies underscore TAP2's importance in adaptive immunity and its potential as a therapeutic or diagnostic target.
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