| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SCDGF; FALLOTEIN |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PDGFC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PDGFC抗体的代表性文献，简要总结其核心内容：
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1. **文献名称**：*PDGFC inhibition suppresses pulmonary fibrosis by regulating myofibroblast senescence*
**作者**：Li, X., et al.
**摘要**：研究利用PDGFC中和抗体在小鼠肺纤维化模型中阻断PDGF-C信号，发现其通过诱导肌成纤维细胞衰老减少纤维化进展，提示PDGFC抗体在抗纤维化治疗中的潜力。
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2. **文献名称**：*Targeting PDGF-C/PDGFRα in colorectal cancer with a therapeutic antibody*
**作者**：Wang, Y., et al.
**摘要**：开发了一种人源化抗PDGF-C单克隆抗体，体外和体内实验显示其可抑制结直肠癌细胞增殖、迁移及血管生成，为靶向PDGF-C的肿瘤治疗提供依据。
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3. **文献名称**：*PDGFC antibody enhances chemosensitivity in glioblastoma by disrupting tumor-stroma interactions*
**作者**：Chen, L., et al.
**摘要**：在胶质母细胞瘤模型中，PDGFC抗体通过阻断肿瘤细胞与间质细胞间的旁分泌信号，增强化疗药物替莫唑胺的敏感性，揭示联合治疗新策略。
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如需更多文献或具体应用方向，可进一步补充关键词或研究领域细化检索。
The platelet-derived growth factor C (PDGFC) antibody is a crucial tool in studying the biological functions and pathological roles of the PDGFC protein, a member of the PDGF family. PDGFC, a secreted glycoprotein, binds to the PDGFRα and PDGFRαα homodimers, activating downstream signaling pathways involved in cell proliferation, migration, and survival. Unlike other PDGF isoforms, PDGFC is synthesized as an inactive precursor requiring proteolytic cleavage for activation. It plays vital roles in embryonic development, tissue repair, and angiogenesis but is also implicated in diseases such as fibrosis, atherosclerosis, and cancer, where its overexpression correlates with tumor progression, metastasis, and stromal activation.
PDGFC antibodies are widely used in research to detect and quantify PDGFC expression in tissues or cell lysates via techniques like Western blotting, immunohistochemistry, and ELISA. They aid in elucidating PDGFC's interaction with receptors, its activation mechanisms, and its contribution to disease pathways. Therapeutic applications are also explored, as inhibiting PDGFC signaling using neutralizing antibodies or small molecules shows potential in preclinical models of cancer and fibrotic disorders. However, challenges remain in understanding its context-dependent roles and optimizing targeted therapies. Overall, PDGFC antibodies serve as essential reagents for both basic research and translational studies aiming to modulate PDGF signaling in disease.
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