| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ATOD2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human FLG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇与FLG(Filaggrin，丝聚蛋白)抗体相关的模拟参考文献示例(注：内容为学术场景模拟，非真实文献)：
---
1. **文献名称**: *Autoantibodies against Filaggrin in Atopic Dermatitis: Clinical Implications*
**作者**: Smith A, et al.
**期刊**: *Journal of Allergy and Clinical Immunology* (2020)
**摘要**: 本研究检测了特应性皮炎(AD)患者血清中抗FLG抗体的存在，发现约30%的患者存在FLG自身抗体，且其水平与疾病严重程度呈正相关。研究提示FLG抗体可能通过破坏皮肤屏障功能参与AD的发病机制。
---
2. **文献名称**: *Filaggrin Deficiency and Anti-Filaggrin Antibodies in Ichthyosis Vulgaris*
**作者**: Brown K, et al.
**期刊**: *British Journal of Dermatology* (2018)
**摘要**: 通过免疫组化和ELISA技术分析鱼鳞病患者皮肤样本及血清，发现FLG基因突变导致丝聚蛋白表达缺失，同时患者体内存在抗FLG抗体，可能加重皮肤角质层异常和炎症反应。
---
3. **文献名称**: *Utility of Anti-Filaggrin Antibodies as a Biomarker in Psoriasis*
**作者**: Lee S, et al.
**期刊**: *Experimental Dermatology* (2021)
**摘要**: 研究评估了银屑病患者中抗FLG抗体的诊断价值，发现与健康对照组相比，患者抗体水平显著升高，且与表皮增厚和IL-17通路激活相关，提示FLG抗体可能作为银屑病的新型生物标志物。
---
**备注**：以上文献为模拟生成，实际研究中请通过PubMed、Web of Science等平台检索真实文献。FLG抗体的研究多聚焦于皮肤屏障功能障碍相关疾病(如特应性皮炎、鱼鳞病)及自身免疫机制。
Filaggrin (FLG) antibodies are essential tools in studying the role of filaggrin, a key protein in epidermal differentiation and skin barrier function. Filaggrin is encoded by the FLG gene and synthesized as a large precursor protein, profilaggrin, which is stored in keratohyalin granules within the stratum granulosum of the epidermis. During terminal differentiation, profilaggrin is cleaved into functional filaggrin monomers that aggregate keratin filaments, facilitating the collapse of corneocytes into a flattened, protective stratum corneum. Subsequently, filaggrin undergoes further degradation into hygroscopic amino acids that contribute to skin hydration and pH regulation.
Mutations in the FLG gene are strongly associated with impaired skin barrier integrity, leading to disorders like ichthyosis vulgaris and atopic dermatitis (eczema). FLG antibodies are widely used in immunohistochemistry, immunofluorescence, and Western blotting to detect filaggrin expression levels, localization, and processing defects in research and clinical diagnostics. These antibodies help elucidate pathogenic mechanisms in genetic skin diseases and assess therapeutic interventions targeting barrier repair. Additionally, FLG autoantibodies have been investigated in autoimmune conditions, though their clinical relevance remains less defined. Overall, FLG antibodies are pivotal in advancing understanding of epidermal biology and related pathologies.
×
