| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | T-cell receptor beta chain V region CTL-L17, TCRB |
| WB Predicted band size | 13.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TCRB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-94 amino acids from the Central region of human TCRB. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RRAD抗体的参考文献示例(注：以下为模拟虚构内容，实际文献需通过学术数据库检索验证)：
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1. **文献名称**: *"RRAD as a Biomarker in Type 2 Diabetes: Role in Insulin Resistance"*
**作者**: Moyers JS, et al.
**摘要**: 研究通过免疫印迹(Western blot)和免疫组化(IHC)分析RRAD蛋白在糖尿病模型中的表达，发现RRAD在胰岛素抵抗组织中显著上调，提示其可能通过干扰胰岛素信号通路参与糖尿病病理机制。
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2. **文献名称**: *"RRAD Promotes Lung Cancer Metastasis via GTPase Signaling Pathways"*
**作者**: Wang Y, et al.
**摘要**: 利用RRAD特异性抗体检测肺癌细胞中RRAD的定位与表达，证实RRAD通过激活Rho-GTPase通路增强肿瘤细胞迁移和侵袭能力，为癌症治疗提供潜在靶点。
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3. **文献名称**: *"Interaction of RRAD with Calcineurin: Implications for Cellular Motility"*
**作者**: Reynet C, Kahn CR
**摘要**: 研究采用免疫共沉淀(Co-IP)和免疫荧光技术，揭示RRAD与钙调神经磷酸酶(calcineurin)的相互作用，调控细胞骨架重组和迁移功能，为RRAD在非代谢疾病中的作用提供证据。
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4. **文献名称**: *"Multifaceted Roles of RRAD: From Diabetes to Cancer"* (综述)
**作者**: Zhang L, et al.
**摘要**: 综述总结了RRAD在不同疾病中的分子机制，强调抗体技术在RRAD蛋白检测中的应用(如ELISA、流式细胞术)，并讨论其作为治疗靶点的潜力。
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**建议**：通过PubMed、Web of Science或Google Scholar检索真实文献时，可使用关键词“RRAD antibody”、“RRAD GTPase”或“RRAD in disease”。
RRAD (Ras-related associated with diabetes) is a small GTP-binding protein encoded by the *RRAD* gene, initially identified for its role in insulin resistance and type 2 diabetes. It regulates glucose uptake by interfering with insulin signaling pathways, particularly through interactions with key components like the insulin receptor and Akt. Beyond metabolic disorders, RRAD overexpression has been linked to cancers, including lung and breast cancer, where it promotes tumor progression via pathways like MAPK/ERK.
RRAD antibodies are tools used to detect and study RRAD protein expression in research and diagnostics. They aid in elucidating its cellular localization, interaction partners, and disease-related mechanisms. In autoimmune contexts, anti-RRAD antibodies have been explored as potential biomarkers, though their clinical relevance remains under investigation. Commercial RRAD antibodies are typically developed in rabbit or mouse hosts, targeting specific epitopes for applications in Western blot, immunohistochemistry, or immunofluorescence.
Recent studies highlight RRAD's dual role in metabolism and oncology, driving interest in therapeutic targeting. However, antibody specificity and validation challenges persist, emphasizing the need for rigorous testing in diverse biological models. Overall, RRAD antibodies remain critical for advancing understanding of its pathophysiological roles.
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