| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | HUP48 |
| WB Predicted band size | 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PAX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于PAX1抗体的3篇参考文献示例(注：文献信息为示例，建议通过学术数据库核实具体内容)：
---
1. **标题**：*PAX1 Expression in Thymic Epithelial Tumors: A Comparative Immunohistochemical Study*
**作者**：Smith A, et al.
**摘要**：本研究通过免疫组化(使用PAX1特异性单克隆抗体)分析了胸腺上皮肿瘤中PAX1蛋白的表达水平，发现其表达与肿瘤分化程度相关，提示PAX1可能作为诊断标志物。
---
2. **标题**：*Epigenetic Silencing of PAX1 in Nasopharyngeal Carcinoma via Promoter Methylation*
**作者**：Lai HC, et al.
**摘要**：研究结合甲基化特异性PCR和Western blot(使用抗PAX1抗体)，证实鼻咽癌中PAX1因启动子甲基化导致蛋白表达下调，可能与肿瘤侵袭性相关。
---
3. **标题**：*Developmental Role of PAX1 in Skeletal Morphogenesis: Insights from Mouse Models*
**作者**：Burton D, et al.
**摘要**：通过免疫荧光染色(使用PAX1多克隆抗体)分析小鼠胚胎脊椎发育，发现PAX1在体节形成中关键作用，为先天性脊柱畸形机制提供依据。
---
建议通过PubMed或Google Scholar检索“PAX1 antibody”、“PAX1 immunohistochemistry”等关键词获取真实文献。
The PAX1 antibody is a tool used to detect the PAX1 (Paired Box 1) protein, a member of the PAX family of transcription factors critical in embryonic development. PAX1 contains a paired box domain that binds DNA, regulating gene expression involved in tissue differentiation, particularly in skeletal and thymic development. It plays a key role in patterning the vertebral column, thymus, and parathyroid glands by directing mesenchymal cell differentiation. Dysregulation of PAX1 is linked to developmental disorders, such as vertebral malformations (e.g., spondylocostal dysostosis) and thymic hypoplasia, as well as cancers like chordoma or squamous cell carcinoma.
PAX1 antibodies are widely utilized in research to study its expression and function via techniques like immunohistochemistry, Western blotting, and immunofluorescence. These antibodies help map PAX1’s spatial-temporal expression during development and assess its aberrations in diseases. Monoclonal antibodies offer high specificity, while polyclonal versions may detect multiple isoforms. Validation often involves knockout controls or peptide blocking to confirm target specificity.
Recent studies explore PAX1’s potential as a biomarker for cancer prognosis or as a therapeutic target. Its role in epithelial-mesenchymal interactions and stem cell regulation also makes it relevant in regenerative medicine. However, challenges remain in standardizing antibody performance across experimental models. Overall, PAX1 antibodies remain vital for unraveling developmental pathways and disease mechanisms.
×
