| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PRL3; PRL-3; PRL-R |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PTP4A3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PTP4A3(PRL-3)抗体的3篇示例文献(内容为假设性示例，供参考)：
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1. **文献名称**: *PTP4A3/PRL-3 Antibody Development for Targeted Cancer Therapy*
**作者**: Zhang Y, et al.
**摘要**: 本研究开发了一种高特异性抗PTP4A3的单克隆抗体，通过体外实验验证其与PTP4A3蛋白的结合能力，并证明其可抑制结肠癌细胞迁移和侵袭，为靶向PTP4A3的癌症治疗提供潜在工具。
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2. **文献名称**: *Role of PTP4A3 in Metastasis: Insights from Antibody-Based Functional Inhibition*
**作者**: Lee S, Kim H.
**摘要**: 利用抗PTP4A3抗体阻断其磷酸酶活性，发现PTP4A3通过调控MAPK信号通路促进黑色素瘤转移。抗体干预显著降低小鼠模型中肺转移灶数量，提示其作为抗转移策略的潜力。
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3. **文献名称**: *Diagnostic Potential of PTP4A3-Specific Antibodies in Ovarian Cancer*
**作者**: Müller C, et al.
**摘要**: 通过免疫组化分析发现，PTP4A3抗体在卵巢癌组织中高表达，且与患者不良预后相关。该抗体可作为生物标志物用于早期诊断和分层治疗。
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注：以上文献为示例，实际引用需查询真实数据库(如PubMed)。如需具体文献，建议使用关键词“PTP4A3 antibody”或“PRL-3 antibody”检索相关数据库。
The PTP4A3 antibody targets the protein tyrosine phosphatase 4A3 (PTP4A3), also known as PRL-3 (phosphatase of regenerating liver-3). PTP4A3 is a member of the PRL phosphatase family, implicated in regulating cellular signaling pathways associated with cell proliferation, migration, and metastasis. Initially identified for its overexpression in cancer, PTP4A3 is linked to tumor progression, particularly in colorectal, liver, ovarian, and breast cancers. Its role in promoting oncogenesis involves interactions with substrates that modulate cytoskeletal dynamics, growth factor signaling, and extracellular matrix remodeling.
PTP4A3 antibodies are essential tools for studying its expression, localization, and function in both normal and pathological contexts. These antibodies are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect PTP4A3 levels in tissues or cell lines, aiding in cancer research and biomarker discovery. Elevated PTP4A3 expression correlates with poor prognosis, making it a potential therapeutic target. Structurally, PTP4A3 contains a conserved phosphatase domain and a C-terminal prenylation motif critical for membrane association. Antibodies targeting specific epitopes help elucidate its post-translational modifications and interaction networks. Research using PTP4A3 antibodies continues to explore its dual role as a phosphatase and signaling scaffold, offering insights into metastasis mechanisms and strategies for inhibiting tumor progression.
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