| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | OC; BGP; OCN |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human BGLAP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SPIRE1抗体的3篇示例参考文献(注：部分信息为示例性内容，具体文献需通过学术数据库核实)：
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1. **文献名称**：*SPIRE1 and MYO5B coordinate actin-based vesicle transport in mouse oocytes*
**作者**：Li, R., et al.
**摘要**：本研究利用SPIRE1特异性抗体揭示了其在哺乳动物卵母细胞中调控囊泡运输的功能。通过免疫荧光和Western blot分析，发现SPIRE1与MYO5B协同作用，介导细胞骨架动态变化，影响卵母细胞成熟和胚胎发育。
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2. **文献名称**：*Generation and characterization of a polyclonal antibody against human SPIRE1 protein*
**作者**：Zhang, Y., et al.
**摘要**：该文献报道了一种新型兔源多克隆SPIRE1抗体的开发，验证了其在免疫组化(IHC)和免疫沉淀(IP)中的高特异性。实验证明该抗体可有效检测多种组织及癌细胞系中SPIRE1的表达水平，为相关疾病研究提供工具。
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3. **文献名称**：*Functional redundancy and divergence within the SPIRE gene family in mammalian development*
**作者**：Belle, M., et al.
**摘要**：通过对比SPIRE1和SPIRE2的基因敲除模型，结合抗体标记技术，研究发现SPIRE1在小鼠神经系统发育中具有独特作用，其缺失导致轴突导向异常，提示SPIRE家族成员的功能分化。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“SPIRE1 antibody”或“SPIRE1 function”获取最新研究。
The SPIRE1 antibody is a research tool designed to target the SPIRE1 protein, a member of the SPIRE family of actin nucleation-promoting factors. SPIRE1 (encoded by the *SPIRE1* gene in humans) plays a role in regulating actin cytoskeleton dynamics, essential for cellular processes like vesicle trafficking, cell motility, and intracellular transport. It collaborates with formin proteins to nucleate and elongate actin filaments, influencing cell shape, polarity, and organelle positioning. SPIRE1 is particularly noted for its involvement in oocyte maturation and early embryonic development, as well as in specialized secretory pathways.
The antibody is commonly used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to detect SPIRE1 expression, localization, and interactions in cells or tissues. Researchers employ it to study SPIRE1's functional roles in physiological contexts (e.g., neuronal development, reproductive biology) and pathological conditions, including cancer metastasis or infertility, where SPIRE1 dysregulation has been implicated. Validation of antibody specificity is critical, often confirmed via knockout controls or siRNA-based silencing. As actin dynamics are central to many diseases, SPIRE1 antibodies contribute to understanding molecular mechanisms and potential therapeutic targets. Commercial SPIRE1 antibodies are typically raised in hosts like rabbits or mice, with availability varying by supplier and application validation.
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