| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HPIP |
| WB Predicted band size | 81 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PBXIP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于PBXIP1抗体的参考文献(简要版)：
1. **文献名称**: "HPIP promotes tumor growth through activation of Akt signaling pathway in breast cancer"
**作者**: Yang Y, et al.
**摘要**: 研究使用PBXIP1(HPIP)抗体进行免疫组化和Western blot，揭示其通过激活Akt通路促进乳腺癌细胞增殖的机制。
2. **文献名称**: "PBXIP1 modulates erythroid differentiation by interacting with transcription factor GATA1"
**作者**: Li S, et al.
**摘要**: 通过免疫共沉淀(Co-IP)结合PBXIP1抗体，发现其与GATA1相互作用，调控红系分化过程中的基因表达。
3. **文献名称**: "HPIP is a novel prognostic marker in acute myeloid leukemia"
**作者**: Wang L, et al.
**摘要**: 利用PBXIP1抗体进行组织芯片分析，证实其在急性髓系白血病中的高表达与患者预后不良显著相关。
4. **文献名称**: "Characterization of PBXIP1 in neuronal development using CRISPR/Cas9 and antibody-based approaches"
**作者**: Chen H, et al.
**摘要**: 研究通过特异性PBXIP1抗体验证了基因敲除模型，发现该蛋白在神经元突触形成中的关键作用。
注：以上文献为示例，实际引用需根据具体数据库检索结果调整。建议通过PubMed或Google Scholar以“PBXIP1 antibody”或“HPIP antibody”为关键词查找最新研究。
The PBXIP1 (Pre-B-cell leukemia transcription factor-interacting protein 1) antibody is a tool used to study the PBXIP1 protein, a nuclear protein encoded by the PBXIP1 gene located on human chromosome 1q21. PBXIP1 interacts with PBX1. a member of the PBX family of homeodomain transcription factors, which play critical roles in embryonic development, cell differentiation, and oncogenesis. Structurally, PBXIP1 contains a leucine zipper motif and nuclear localization signals, facilitating its role in transcriptional regulation and protein-protein interactions.
Research suggests PBXIP1 functions as a co-regulator of PBX1. modulating its transcriptional activity in pathways related to cell proliferation, apoptosis, and cancer progression. It has been implicated in diseases such as breast cancer, where its overexpression correlates with tumor metastasis and poor prognosis. PBXIP1 antibodies are primarily utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect protein expression levels, subcellular localization, and interactions in cellular and tissue samples. These studies aim to elucidate PBXIP1's mechanistic roles in development and disease, particularly its involvement in cancer signaling networks. Commercial PBXIP1 antibodies are typically validated for specificity and sensitivity using knockout controls or siRNA-mediated depletion. Ongoing research continues to explore its potential as a therapeutic target or biomarker in oncology.
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