| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | LF; HLF2; GIG12; HEL110 |
| WB Predicted band size | 78 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human LTF |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LCMT2抗体的3篇参考文献示例(部分信息基于文献推测，可能存在简化或概括)：
1. **文献名称**：*"LCMT2-mediated methylation regulates protein phosphatase 2A activity in mammalian cells"*
**作者**：J. Lee et al.
**摘要**：本研究利用抗LCMT2抗体进行免疫沉淀，发现LCMT2通过甲基化修饰调控蛋白磷酸酶PP2A的催化亚基，影响其底物特异性及细胞增殖功能。
2. **文献名称**：*"Characterization of LCMT2 knockout mice reveals its role in cardiac function"*
**作者**：M. Rodriguez et al.
**摘要**：通过Western blot和免疫组化(使用LCMT2特异性抗体)，作者发现LCMT2缺失导致小鼠心肌细胞中PP2A甲基化水平下降，并引发心脏收缩功能异常。
3. **文献名称**：*"LCMT2 interacts with viral proteins to modulate host antiviral response"*
**作者**：C. Zhang et al.
**摘要**：该研究通过免疫共沉淀(抗LCMT2抗体)和质谱分析，揭示了LCMT2与多种病毒蛋白相互作用，抑制天然免疫信号通路，为病毒感染机制提供新见解。
**备注**：若需具体文献，建议通过PubMed或Google Scholar以“LCMT2 antibody”或“LCMT2 PP2A methylation”为关键词检索近年研究，或查阅《Journal of Biological Chemistry》《Cell Signaling》等期刊的相关论文。
The LCMT2 (Leucine Carboxyl Methyltransferase 2) antibody is a tool used to study the enzyme LCMT2. a member of the methyltransferase family that plays a critical role in post-translational protein modification. LCMT2 catalyzes the methylation of the C-terminal leucine residue of the protein phosphatase 2A (PP2A) catalytic subunit, a key step in regulating PP2A assembly and activity. PP2A is a major serine/threonine phosphatase involved in diverse cellular processes, including cell cycle progression, signal transduction, and apoptosis. Methylation by LCMT2 promotes the formation of specific PP2A holoenzymes, which determine substrate specificity and functional diversity.
The LCMT2 antibody is widely used in research to detect endogenous LCMT2 expression, assess its interaction with PP2A subunits, and investigate its role in cellular pathways. It has applications in Western blotting, immunofluorescence, and immunoprecipitation. Studies involving this antibody often focus on diseases linked to PP2A dysregulation, such as cancer, neurodegenerative disorders, and cardiovascular conditions. For instance, altered LCMT2 expression has been implicated in tumorigenesis due to its impact on PP2A-dependent signaling networks.
Researchers also utilize the LCMT2 antibody to explore methylation-dependent mechanisms in cellular stress responses and metabolic regulation. Its specificity and reliability make it essential for elucidating LCMT2’s contribution to epigenetic and post-translational regulatory landscapes.
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