| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ATAC2; CRP2BP; CSRP2BP; PRO1194; dJ717M23.1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human KAT14 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于KAT14抗体的参考文献概要(文献标题与内容为模拟生成，仅供参考)：
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1. **标题**: *KAT14 acetyltransferase complex coordinates with MYC to regulate transcriptional elongation in leukemia*
**作者**: Li et al. (2021)
**摘要**: 本研究利用KAT14特异性抗体进行ChIP-seq分析，发现KAT14作为MYC复合体的协同因子，通过乙酰化组蛋白H3K9调控白血病细胞中致癌基因的转录延伸，其缺失导致肿瘤生长抑制。
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2. **标题**: *Characterization of KAT14 knockout mice reveals its role in embryonic development*
**作者**: Smith & Wang (2019)
**摘要**: 通过KAT14抗体进行免疫组化与Western blot验证，发现KAT14敲除小鼠胚胎发育异常，表型与心脏和神经管缺陷相关，表明其在早期发育中调控关键基因的染色质可及性。
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3. **标题**: *Proteomic analysis identifies KAT14 as a component of the Tip60 complex in DNA damage repair*
**作者**: Garcia-Rodriguez et al. (2020)
**摘要**: 使用KAT14抗体进行免疫共沉淀实验，证实KAT14与Tip60组蛋白乙酰转移酶复合体相互作用，参与DNA损伤修复通路，调控ATM激酶活性和同源重组修复效率。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词(如"KAT14 antibody"、"KAT14 histone acetyltransferase")，并筛选近5年高被引论文。
The KAT14 antibody is a tool used to study the KAT14 protein, a component of the histone acetyltransferase (HAT) complex. KAT14. also known as CSRP2BP or CREBBP/EP300-associated factor, belongs to the KAT2 family of acetyltransferases. It plays a role in chromatin remodeling by acetylating histones (e.g., H3 and H4), thereby regulating gene transcription. KAT14 interacts with transcriptional coactivators like CREB-binding protein (CBP) and p300. contributing to diverse cellular processes, including cell cycle regulation, DNA repair, and differentiation.
Research on KAT14 has linked it to cancer progression, neurodegenerative disorders, and developmental pathways. For example, dysregulation of KAT14-mediated acetylation may influence oncogene expression or tumor suppressor silencing. Antibodies against KAT14 are essential for detecting its expression, localization, and interactions in cells. They are widely used in techniques like chromatin immunoprecipitation (ChIP-seq), Western blotting, and immunofluorescence to explore its functional roles.
Commercial KAT14 antibodies are typically developed in rabbit or mouse hosts, targeting specific epitopes (e.g., N-terminal regions). Validation often includes knockout cell lines to confirm specificity. Researchers must verify cross-reactivity and batch consistency, as nonspecific binding can occur. Current studies focus on KAT14's involvement in disease mechanisms and its potential as a therapeutic target, driving demand for reliable antibodies in both basic and translational research.
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