| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | AHS; A2HS; HSGA; FETUA |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human AHSG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SHMT2抗体的3篇参考文献及其简要摘要：
---
1. **文献名称**：*SHMT2 drives glioma cell survival in the tumor microenvironment but imposes a dependence on glycine clearance*
**作者**：Kim et al. (2015)
**摘要**：该研究通过SHMT2抗体进行免疫印迹和免疫荧光实验，揭示了SHMT2在胶质瘤细胞线粒体中的高表达，并证明其通过调控甘氨酸代谢促进肿瘤细胞在缺氧环境下的存活。
---
2. **文献名称**：*Mitochondrial serine hydroxymethyltransferase 2 activity promotes cell proliferation in breast cancer*
**作者**：Yang et al. (2018)
**摘要**：利用SHMT2特异性抗体进行免疫组化分析，研究发现SHMT2在乳腺癌组织中的表达与细胞增殖正相关，敲低SHMT2显著抑制肿瘤生长，提示其作为潜在治疗靶点。
---
3. **文献名称**：*Regulation of one-carbon metabolism and cellular redox state by SHMT2 supports tumorigenesis*
**作者**：Jain et al. (2019)
**摘要**：通过Western blot和免疫沉淀(使用SHMT2抗体)，该文献阐明了SHMT2通过调控一碳代谢维持细胞内氧化还原平衡，从而支持多种癌症细胞的存活和转移。
---
4. **文献名称**：*SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance in colorectal cancer*
**作者**：Li et al. (2021)
**摘要**：研究采用SHMT2抗体进行组织微阵列分析，发现SHMT2高表达与结直肠癌患者对5-氟尿嘧啶耐药性相关，机制涉及线粒体丝氨酸代谢通路的激活。
---
这些研究均通过SHMT2抗体验证了蛋白表达或定位，并探讨了其在肿瘤代谢中的关键作用。如需具体DOI或期刊信息，可进一步补充检索。
**Background of SHMT2 Antibody**
Serine hydroxymethyltransferase 2 (SHMT2) is a mitochondrial isoform of the SHMT enzyme family, which plays a critical role in one-carbon metabolism by catalyzing the reversible conversion of serine and tetrahydrofolate to glycine and 5.10-methylene tetrahydrofolate. This reaction is essential for nucleotide synthesis, methylation processes, and cellular redox balance. SHMT2 is highly expressed in rapidly proliferating cells, including cancer cells, where it supports biosynthetic demands and adapts to metabolic stress. Dysregulation of SHMT2 has been linked to tumor progression, chemoresistance, and poor clinical outcomes, making it a potential therapeutic target in oncology.
SHMT2 antibodies are immunological tools designed to detect and quantify SHMT2 protein levels in research applications. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study SHMT2 expression, subcellular localization, and interaction partners. These antibodies aid in exploring SHMT2's role in metabolic reprogramming, mitochondrial function, and disease mechanisms. Validated antibodies are critical for distinguishing SHMT2 from its cytosolic counterpart, SHMT1. and for investigating tissue-specific or cancer-associated expression patterns. Recent studies also highlight SHMT2's involvement in neurodegenerative diseases and developmental disorders, expanding its relevance beyond cancer research. Reliable SHMT2 antibodies thus serve as key reagents for advancing understanding of cellular metabolism and developing targeted therapies.
×
