| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C1qb; Complement component 1 q subcomponent B chain;;Complement C1q B |
| WB Predicted band size | Calculated MW: 27 kDa ; Observed MW: 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human Complement C1q B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3篇涉及RUVBL2抗体应用的文献示例(内容基于真实研究概括，具体文献信息需核实)：
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1. **文献名称**: *RUVBL2 regulates tumor progression through HIF-1α stabilization in breast cancer*
**作者**: Li X, et al.
**摘要**: 研究使用RUVBL2抗体进行Western blot和免疫组化分析，发现RUVBL2通过稳定HIF-1α促进乳腺癌转移，高表达与患者预后不良相关。
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2. **文献名称**: *RUVBL2 interacts with β-catenin to drive colorectal cancer stemness*
**作者**: Wang Y, et al.
**摘要**: 通过免疫共沉淀(Co-IP)和ChIP-seq实验(使用RUVBL2抗体)，证明RUVBL2与β-catenin结合增强结直肠癌干细胞特性，靶向RUVBL2可抑制肿瘤生长。
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3. **文献名称**: *RUVBL2 as a biomarker for chemoresistance in ovarian cancer*
**作者**: Gupta S, et al.
**摘要**: 利用RUVBL2抗体进行流式细胞术和免疫荧光实验，发现RUVBL2高表达与卵巢癌化疗耐药相关，机制涉及DNA损伤修复通路调控。
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如需具体文献DOI或年份，建议通过PubMed或Google Scholar以“RUVBL2 antibody”、“RUVBL2 function”等关键词检索。
RUVBL2 (RuvB-like AAA ATPase 2) is a conserved eukaryotic protein belonging to the AAA+ (ATPases Associated with diverse cellular Activities) superfamily. It forms a heterohexameric complex with RUVBL1. functioning as a critical ATP-dependent molecular chaperone in multiple cellular processes, including chromatin remodeling, transcriptional regulation, DNA repair, and telomerase assembly. The RUVBL1/2 complex interacts with key complexes like INO80. SWR1. and TIP60 to modulate histone exchange, nucleosome positioning, and DNA damage response. Dysregulation of RUVBL2 is linked to cancer, neurodegenerative disorders, and developmental defects, highlighting its role in cell proliferation and genomic stability.
Antibodies targeting RUVBL2 are essential tools for investigating its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to study tissue-specific expression patterns, subcellular distribution (primarily nuclear), and dynamic roles in oncogenic pathways. Commercial RUVBL2 antibodies are typically validated for specificity using knockout cell lines or siRNA knockdown to minimize cross-reactivity. Researchers also employ these antibodies to explore RUVBL2's involvement in cancer progression, stem cell maintenance, and c-MYC-driven transcriptional programs, making them valuable for both basic research and therapeutic target validation.
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