| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | P2; MP2; FABP8; M-FABP |
| WB Predicted band size | 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ARMC8抗体的3篇参考文献示例(内容基于模拟生成，非真实文献)：
1. **文献名称**：*ARMC8 regulates β-catenin degradation through the ubiquitin-proteasome pathway in colorectal cancer*
**作者**：Zhang Y, et al.
**摘要**：本研究利用ARMC8特异性抗体，揭示了ARMC8通过与β-catenin相互作用促进其泛素化降解，从而抑制结直肠癌Wnt信号通路的异常激活。实验表明，ARMC8抗体在Western blot和免疫共沉淀(Co-IP)中表现出高特异性。
2. **文献名称**：*CRISPR screening identifies ARMC8 as a ciliopathy-associated gene required for ciliary assembly*
**作者**：Smith J, et al.
**摘要**：通过CRISPR筛选和ARMC8抗体免疫荧光染色，发现ARMC8缺失导致纤毛结构缺陷。研究证实ARMC8抗体可定位其在纤毛基部的表达，并揭示其与CUL3-E3连接酶复合物的功能关联。
3. **文献名称**：*Development of a monoclonal antibody against ARMC8 for the diagnosis of Joubert syndrome*
**作者**：Li H, et al.
**摘要**：本研究报道了一种新型ARMC8单克隆抗体的开发，该抗体通过ELISA和免疫组化验证，可用于Joubert综合征患者的ARMC8蛋白水平检测，为疾病诊断提供了潜在工具。
(注：以上文献为示例，实际引用请根据真实数据库检索结果调整。)
The ARMC8 (Armadillo Repeat Containing 8) protein is a component of the cullin-RING ubiquitin ligase (CRL) complex, which regulates ubiquitin-mediated protein degradation. It contains multiple Armadillo (ARM) repeats, structural motifs involved in protein-protein interactions. ARMC8 plays a critical role in substrate recognition and recruitment for the CRL complex, particularly in the β-TrCP1/2 (BTRC/FBXW11)-mediated ubiquitination pathway, impacting processes like Wnt/β-catenin signaling, cell cycle regulation, and DNA damage response. Dysregulation of ARMC8 has been linked to cancers, developmental disorders, and immune dysfunctions.
ARMC8 antibodies are essential tools for studying its expression, localization, and interactions. They are commonly used in techniques such as Western blotting, immunoprecipitation (IP), and immunofluorescence (IF) to investigate ARMC8's role in cellular pathways. Many commercially available antibodies target specific epitopes, often within the ARM repeat domains, and are validated for specificity using knockout cell lines or siRNA knockdown. Research applications include exploring ARMC8's involvement in tumor progression, ciliopathies, and viral infection mechanisms (e.g., HIV-1).
Recent studies highlight ARMC8's potential as a therapeutic target, driving demand for high-quality antibodies to support mechanistic and translational research. Validation data, including molecular weight confirmation (~50-55 kDa) and cross-reactivity profiles, are critical for ensuring experimental reliability.
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