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Rabbit Polyclonal PISD Antibody

  • 中文名: PISD抗体
  • 别    名: PSD; PSDC; PSSC; DJ858B16; dJ858B16.2
货号: IPDX02686
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于PISD(磷脂酰肌醇合成酶)抗体的3篇模拟参考文献示例,供参考:

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1. **文献名称**:*Mitochondrial PISD modulates cristae structure and apoptosis in neurodegenerative disease*

**作者**:Smith J, et al. (2020)

**摘要**:本研究利用特异性PISD抗体,发现PISD蛋白通过调控线粒体膜磷脂组成影响嵴结构稳定性。在阿尔茨海默病模型中,PISD表达下降导致线粒体功能异常并加速神经元凋亡。

2. **文献名称**:*PISD as a therapeutic target in chemotherapy-resistant lung cancer*

**作者**:Zhang L, et al. (2018)

**摘要**:通过PISD抗体检测发现,肺癌细胞中PISD高表达与化疗耐药性相关。抑制PISD活性可破坏线粒体膜完整性,增强顺铂诱导的癌细胞死亡,提示其作为联合治疗靶点的潜力。

3. **文献名称**:*PISD deficiency disrupts hepatic lipid metabolism via impaired phospholipid remodeling*

**作者**:Chen R, et al. (2021)

**摘要**:研究使用PISD抗体分析小鼠肝脏组织,发现PISD缺失导致磷脂酰肌醇代谢异常,引发脂质堆积和炎症反应,为代谢相关脂肪肝的机制提供了新见解。

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**说明**:

- 以上文献为示例,实际引用时需核实真实来源(可通过PubMed/Google Scholar搜索关键词如“PISD antibody”、“phosphatidylserine decarboxylase”)。

- 若需具体领域文献(如结构生物学或疾病应用),建议补充研究背景以便精准推荐。

背景信息

The Phosphatidylserine Decarboxylase (PISD) antibody is a tool used to study the PISD enzyme, a key player in phospholipid metabolism. PISD catalyzes the decarboxylation of phosphatidylserine (PS) to phosphatidylethanolamine (PE), a critical step in maintaining membrane lipid homeostasis, particularly in mitochondria. This enzyme is embedded in the inner mitochondrial membrane and is essential for mitochondrial function, membrane integrity, and cellular processes like autophagy and apoptosis. Dysregulation of PISD has been linked to metabolic disorders, neurodegenerative diseases, and cancer, highlighting its biological significance. Researchers employ PISD antibodies to detect and quantify PISD protein levels, assess its subcellular localization, and investigate its role in disease mechanisms. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also explore PISD's potential as a therapeutic target, particularly in cancers reliant on mitochondrial lipid synthesis. The development of specific PISD antibodies has advanced understanding of lipid dynamics in health and disease, offering insights into mitochondrial dysfunction and opportunities for diagnostic or therapeutic innovations.

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