Rabbit Polyclonal RSPH14 Antibody

The RSPH14 antibody is designed to target the Radial Spoke Head 14 (RSPH14) protein, a component of the radial spoke complex in cilia and flagella. Radial spokes are evolutionarily conserved macromolecular structures critical for regulating the motility and bending of these hair-like organelles. RSPH14. part of the radial spoke head domain, is thought to contribute to the stability and coordination of dynein arm activity, ensuring proper ciliary beating patterns. Mutations in RSPH genes, including RSPH14. have been linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by impaired mucociliary clearance, leading to chronic respiratory infections, infertility, and situs abnormalities. Research on RSPH14 antibodies primarily focuses on elucidating ciliary ultrastructure, molecular mechanisms underlying PCD, and potential diagnostic applications. These antibodies are commonly used in techniques like immunofluorescence, Western blotting, or immunohistochemistry to localize RSPH14 in ciliated tissues or model organisms (e.g., mice, zebrafish). Studies utilizing RSPH14 antibodies have also explored its role beyond motility, including sensory functions and signaling pathways in development. However, the functional specifics of RSPH14 remain less characterized compared to other radial spoke proteins, warranting further investigation into its interactions and disease-associated variants.