| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | HMGX1; HMGXB1 |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human HMG20A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HMG20A抗体的参考文献示例(注：以下文献信息为假设性示例，实际文献需通过学术数据库核实)：
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1. **文献名称**：*HMG20A regulates neurogenic differentiation through chromatin remodeling*
**作者**：Chen, L., et al.
**摘要**：研究利用HMG20A抗体进行染色质免疫沉淀(ChIP)，揭示了HMG20A通过与染色质重塑复合体相互作用调控神经干细胞分化的分子机制。
2. **文献名称**：*HMG20A modulates pancreatic cancer progression via Wnt/β-catenin signaling*
**作者**：Zhang, Y., et al.
**摘要**：通过Western blot和免疫组化(IHC)分析，发现HMG20A在胰腺癌中高表达，其抗体用于检测蛋白水平，研究证实其通过调控Wnt通路促进肿瘤侵袭。
3. **文献名称**：*HMG20A is essential for embryonic stem cell pluripotency*
**作者**：Kim, S., et al.
**摘要**：利用HMG20A抗体进行免疫荧光和Co-IP实验，证明HMG20A与多能性因子OCT4相互作用，维持胚胎干细胞的自我更新能力。
4. **文献名称**：*HMG20A deficiency disrupts cortical neuron migration in mice*
**作者**：Wang, H., et al.
**摘要**：在小鼠模型中，通过HMG20A抗体检测蛋白表达，发现其缺失导致神经元迁移缺陷，提示其在脑发育中的关键作用。
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**建议**：可通过PubMed、Google Scholar等平台以关键词“HMG20A antibody”或“HMG20A function”检索真实文献，并筛选涉及该抗体应用的实验研究。
The HMG20A (High Mobility Group 20A) antibody is a tool used to study the HMG20A protein, a member of the non-histone chromosomal high mobility group (HMG) protein family. HMG20A, also termed HMGX or SOX21-like, contains an HMG-box domain that enables DNA binding and chromatin interaction. It plays roles in transcriptional regulation, chromatin remodeling, and epigenetic control, particularly in neural development and differentiation. Studies link HMG20A to neurogenesis, where it may act as a dual regulator—promoting neuronal differentiation while suppressing glial lineage commitment. It also interacts with chromatin-remodeling complexes like the Polycomb repressive complex (PRC2), influencing gene silencing.
HMG20A dysregulation is implicated in neurodevelopmental disorders (e.g., autism spectrum disorders) and cancers, including neuroblastoma and leukemia. The antibody is widely used in research to detect HMG20A expression levels, subcellular localization (primarily nuclear), and protein-protein interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its applications extend to exploring HMG20A's role in stem cell pluripotency, neuronal fate determination, and disease mechanisms. Recent work highlights its potential as a biomarker or therapeutic target in malignancies and neurological conditions. Commercial HMG20A antibodies are typically validated for specificity in human, mouse, or rat models.
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