| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C7orf42 |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TMEM248 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于TMEM248抗体的假设参考文献示例(请注意，这些文献为虚构，仅用于演示格式)：
---
1. **文献名称**：TMEM248 modulates cell proliferation via ERK signaling in colorectal cancer
**作者**：Zhang Y, et al.
**摘要**：本研究通过TMEM248抗体进行免疫组化和Western blot分析，发现TMEM248在结直肠癌中高表达，并通过激活ERK信号通路促进肿瘤细胞增殖。
2. **文献名称**：Characterization of a novel polyclonal antibody against TMEM248 for subcellular localization studies
**作者**：Li H, et al.
**摘要**：开发并验证了一种兔源多克隆TMEM248抗体，通过免疫荧光和免疫电镜技术确认TMEM248主要定位于细胞核膜及内质网，为后续功能研究提供工具。
3. **文献名称**：TMEM248 interacts with viral proteins and enhances influenza A virus replication
**作者**：Smith J, et al.
**摘要**：利用TMEM248抗体进行免疫共沉淀实验，发现TMEM248与流感病毒基质蛋白M1相互作用，增强病毒在宿主细胞内的复制效率。
4. **文献名称**：TMEM248 deficiency exacerbates oxidative stress-induced neuronal apoptosis
**作者**：Wang L, et al.
**摘要**：通过TMEM248抗体敲低实验，发现TMEM248缺失导致神经元线粒体功能障碍，加剧氧化应激诱导的细胞凋亡。
---
**注意**：以上文献及摘要均为模拟示例，实际研究中请通过PubMed、Google Scholar等平台检索真实文献。若需进一步协助查找实际论文，请提供更多具体信息。
The TMEM248 antibody is designed to target the transmembrane protein 248 (TMEM248), a poorly characterized protein encoded by the *TMEM248* gene in humans. TMEM248 is a member of the transmembrane (TMEM) protein family, which comprises diverse proteins involved in cellular processes such as membrane transport, signaling, and organelle organization. Structurally, TMEM248 is predicted to contain multiple transmembrane domains, suggesting its potential role in membrane-associated functions. However, its precise physiological role remains unclear. Limited studies associate TMEM248 with cellular stress responses, immune regulation, and possibly cancer progression, though mechanistic insights are sparse.
The TMEM248 antibody is primarily used in research to detect and visualize the protein's expression, localization, and interactions in cells or tissues. It has applications in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Commercial TMEM248 antibodies are typically produced in hosts such as rabbits or mice, with validation data confirming specificity through knockdown/knockout controls or peptide blocking assays. Researchers utilize these antibodies to explore TMEM248's expression patterns in disease models, particularly in cancers or immune-related conditions, aiming to clarify its biological relevance. Despite its limited characterization, TMEM248 remains a subject of interest for unraveling novel membrane protein functions, and its antibody serves as a critical tool for advancing these investigations.
×
