Rabbit Polyclonal CPSF1 Antibody

The CPSF1 (Cleavage and Polyadenylation Specificity Factor 1) antibody is a key reagent used to study the CPSF complex, a critical player in mRNA 3′-end processing. CPSF1. a core subunit of this multi-protein complex, recognizes the polyadenylation signal (AAUAAA) in pre-mRNAs and coordinates cleavage and polyadenylation during transcription termination. This process ensures proper maturation of mRNA, impacting gene expression stability and translation. Structurally, CPSF1 contains a conserved N-terminal domain for RNA recognition and a C-terminal region mediating interactions with other processing factors like CPSF2 and Fip1. Antibodies targeting CPSF1 are widely utilized in molecular biology research to investigate RNA processing mechanisms, transcriptional regulation, and dysregulation in diseases such as cancer, viral infections, or developmental disorders. They enable detection of CPSF1 expression levels, subcellular localization (primarily nuclear), and protein-protein interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Recent studies also explore CPSF1's non-canonical roles in DNA repair and cell cycle control, expanding its relevance beyond RNA metabolism. The availability of specific CPSF1 antibodies continues to support advances in understanding post-transcriptional gene regulation and its therapeutic implications.