| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CRN7; POD1; 0610011B16Rik |
| WB Predicted band size | 101 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CORO7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CORO7抗体的示例参考文献(注：部分为虚构内容，仅作示例参考)：
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1. **文献名称**: *"Characterization of CORO7 in lysosomal trafficking using a novel polyclonal antibody"*
**作者**: Zhang L, et al.
**摘要**: 本研究开发了一种兔源多克隆CORO7抗体，通过重组蛋白免疫制备，验证其在免疫印迹(WB)和免疫荧光(IF)中的特异性，揭示了CORO7在溶酶体膜运输中的调控作用。
2. **文献名称**: *"CORO7 modulates neuronal dendritic complexity via actin cytoskeleton remodeling"*
**作者**: Lee S, et al.
**摘要**: 利用CORO7特异性抗体进行组织染色和蛋白质互作分析，发现CORO7通过结合Arp2/3复合体调控神经元树突发育，抗体在小鼠脑切片中显示高特异性。
3. **文献名称**: *"A role for CORO7 in cancer cell invasion identified by antibody-mediated knockdown validation"*
**作者**: Kumar R, et al.
**摘要**: 通过CORO7抗体结合CRISPR筛选，证实其在上皮-间质转化(EMT)中的作用，抗体用于免疫组化(IHC)显示CORO7在转移性肿瘤中高表达。
4. **文献名称**: *"Generation and application of a monoclonal antibody against human CORO7 for diagnostic studies"*
**作者**: Wang Y, et al.
**摘要**: 报道了一种小鼠单克隆CORO7抗体的制备，应用于ELISA和流式细胞术，提示CORO7可能作为炎症性肠病的潜在生物标志物。
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以上文献摘要概括了CORO7抗体在基础研究(如细胞运输、神经发育)和疾病机制(如癌症、炎症)中的应用，涵盖多克隆/单克隆抗体的开发及实验方法。实际研究中建议通过PubMed或Google Scholar检索最新文献。
The CORO7 antibody targets coronin 7 (CORO7), a member of the coronin protein family characterized by conserved WD40 domains involved in cytoskeletal regulation, vesicular trafficking, and immune responses. Coronin 7. encoded by the *CORO7* gene in humans, is distinct from other coronins due to its unique N-terminal extension and tandem coronin domains. It localizes to the Golgi apparatus and endosomal compartments, where it modulates membrane trafficking and organelle dynamics by interacting with actin filaments and microtubules. CORO7 is implicated in maintaining Golgi structure, secretory pathways, and neuronal development, with studies suggesting roles in autophagy and lysosomal function.
Antibodies against CORO7 are primarily used in research to investigate its expression, intracellular localization, and molecular interactions. They enable detection via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of CORO7 has been linked to neurodevelopmental disorders and cancer, though its precise pathogenic mechanisms remain under exploration. Commercial CORO7 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown. Ongoing studies aim to clarify CORO7's role in cellular homeostasis and disease, highlighting its potential as a therapeutic or diagnostic target.
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