Rabbit Polyclonal CNOT2 Antibody

The CNOT2 antibody is a crucial tool for studying the CNOT2 protein, a core subunit of the CCR4-NOT complex, which plays a pivotal role in post-transcriptional gene regulation. This evolutionarily conserved complex is involved in mRNA deadenylation, degradation, and translational repression, impacting diverse cellular processes like development, stress responses, and metabolism. CNOT2 serves as a scaffolding protein, mediating interactions between the catalytic subunits (e.g., CNOT6/6L/7) and other regulatory components. Its structural domains, including the NOT2 superfamily domain, enable recruitment of deadenylases and RNA-binding proteins. Dysregulation of CNOT2 has been linked to cancers, neurological disorders, and immune diseases, underscoring its biological significance. Researchers use CNOT2 antibodies (often rabbit or mouse monoclonal) to detect protein expression via Western blot, immunoprecipitation, or immunofluorescence. Validated antibodies help investigate CNOT2's role in mRNA turnover, miRNA-mediated silencing, and cellular homeostasis. Specificity is typically confirmed using knockout cell lines. These antibodies are essential for exploring CCR4-NOT complex dynamics and their implications in disease mechanisms or therapeutic targeting.